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OC 14.07 Comparision of AFC and AMH for assessment of ovarian reserve

OC 14.07 Comparision of AFC and AMH for assessment of ovarian reserve. Dr. Sonal Panchal , Dr. C.B.Nagori Dr. Nagori’s Institute for Infertility and IVF, Ahmedabad , India. Aim:

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OC 14.07 Comparision of AFC and AMH for assessment of ovarian reserve

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  1. OC 14.07 Comparision of AFC and AMH for assessment of ovarian reserve Dr. SonalPanchal, Dr. C.B.Nagori Dr. Nagori’s Institute for Infertility and IVF, Ahmedabad, India

  2. Aim: • This study aims to compare the efficacy of AFC & AMH, as markers for ovarian reserve based on computation of correlation between AFC and AMH. Method: • 75 PCO patients + 75 non PCO patients undergoing IVF (BMI : 22 – 26) . • Baseline 3D US -AFC was done for all on day 3. • AMH was measured in all on the same day. • Primary end point was number of follicles > 12 mm on day of hCG • Final end point was ova retrieved on ovum pick up. • Correlation of AFC and AMH was checked with both these endpoints • Correlation of AFC was also checked with AMH.

  3. Table 1:Correlation of AFC & AMH with follicles >12mm on day of hCG for Polycystic and nonPCO category of ovaries N= 75 Correlation between AFC and follicles of > 12mm diameter on the day of hCG and AMH and follicle >12mm on the day of hCG, significant at .01 level at 0.283(99.9% as per Pearson’s correlation coefficient).

  4. Table 2: Correlation of AFC and AMH with ova retrieved on OPU for Polycystic & normal category of ovaries N= 75 (correlation between AFC and AMH and ova retrieved on OPU for both the types of ovaries. significant at 0.01 level)

  5. Table 3:Z score for difference in correlation of AFC and AMH with number of follicles larger than12mm for nonPCO and Polycystic Ovaries. • *Values for Level of Significance 0.0823 (one tailed) and 0.1645 (two tailed test) • * Values for Level of Significance 0.1335 (one tailed) and 0.267 (two tailed test) Table 4:Z score for difference in correlation of AFC and AMH with ova retrieved on OPU for Normal Ovaries and Polycystic Ovaries *Values for Level of Significance 0.2946 (one tailed) and 0.5892 (two tailed test) *Values for Level of Significance 0.3594 (one tailed) and 0.7188 (two tailed test)

  6. Conclusion • AFC & AMH both correlate with each other but have independent significance for estimating follicles larger than 12 mm on the day of hCG. • Difference of correlation coefficient between AFC and AMH for ova retrieved on OPU, is minimally significant in non PCO and is not significant in PCO group . • Z values for both nonpco & pco group are equal to or below the tabulated one tailed significance value, for ova retrieved on OPU. • Therefore for both groups, AFC alone may suffice as a test for estimation of ovarian reserve.

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