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Enhanced sensitivity of pancreatic cancer cells to concurrent inhibition of aberrant Stat3 and EGFR or Src. Soumya Jaganathan, Peibin Yue, and James Turkson. J. Pharmacology and Experimental Therapeutics. Fig. 2. Colo357. HPDEC. Panc-1. Panc-1. Colo-357. i). pErk1. pErk2. Erk1. Erk2.
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Enhanced sensitivity of pancreatic cancer cells to concurrent inhibition of aberrant Stat3 and EGFR or Src Soumya Jaganathan, Peibin Yue, and James Turkson J. Pharmacology and Experimental Therapeutics Fig. 2 Colo357 HPDEC Panc-1 Panc-1 Colo-357 i) pErk1 pErk2 Erk1 Erk2 ii) pAkt Akt Lane 11 12 13 1 2 3 4 5 6 7 8 9 10 - - - - - - - - - 1 μM ZD (h) 1 24 1 24 - - - - - - - - - 100 nM Das (h) 1 24 1 24