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Challenges in Solving Protein Structures: Understanding Failures and Improving Techniques

This article addresses the challenges in solving protein structures, focusing on reasons for failures such as overlaps, signal-to-noise issues, and radiation damage. It discusses lattice damage, site-specific damage, and strategies to overcome these obstacles. The work is supported by various research grants and collaborations.

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Challenges in Solving Protein Structures: Understanding Failures and Improving Techniques

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  1. Why are

  2. we not

  3. solving

  4. more

  5. struct

  6. tures?

  7. James Holton JMHolton@lbl.gov University of California San Francisco and Advanced Light Source Lawrence Berkeley National Laboratory Berkeley, CA 94720 USA This work was supported by contributions from the ALS 8.3.1 participating research team, a University of California Campus-Laboratory Collaboration Grant and grants from the National Institutes of Health: GM74929 and GM24485. Beamline 8.3.1 was funded by the National Science Foundation, the University of California, Berkeley, the University of California, San Francisco and Henry Wheeler. The Advanced Light Source is supported by the Director, Office of Science, Office of Basic Energy Sciences, Materials Sciences Division, of the US Department of Energy under contract No. DE-AC02-05CH11231 at Lawrence Berkeley National Laboratory.

  8. Why do structures fail? Overlaps Signal to Noise Radiation Damage

  9. Radiation Damage Lattice Damage Site-specific Damage

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