ABSTRACT EFFECT OF POLYPLASDONE XL-10 CONCENTRATION ON PHYSICAL

1. ABSTRACT EFFECT OF POLYPLASDONE XL-10 CONCENTRATION ON PHYSICAL CHARACTERISTICS AND DISSOLUTION RATE OF PIROXICAM ORALLY DISINTEGRATING TABLET Rifqika Faradis The research provided improved oral dosage form administered orally that disintegrate rapidly in the saliva without the need of water, named Orally Disintegrating Tablet (ODT). ODT is easy to administer and enhance better patient compliance because usually elderly people experience difficulty in swallowing the conventional dosage forms. Polyplasdone XL-10 as disintegrant was added to the Piroxicam - Lactose - 2 % PVP K-30 granules which were prepared by wet granulation method using Fluid Bed Granulator. The concentration of polyplasdone XL-10 used were 3% and 5%. Then, the tablets were tested in both physical characteristics (hardness, friability value and disintegration time) and dissolution rate. The result of hardness value from F1 - F3 were 4,16  0,16 kP, 4,73  0,25 kP, and 5,30  0,36 kP, friability value were 0,84  0,03 %, 0,74  0,03 %, and 0,66  0,02 %, disintegration times were 73,67  6,03 s, 53,00  1,00 s, and 39,00  1,00 s, and for dissolution rate were 81,48 0,25 %, 81,79  0,84 %, and 82,90  2,18 %. Polyplasdone XL-10 in different concentration had influenced and gave significant difference in the physical characteristics such as the hardness, friability value, and disintegration time. Dissolution efficiency (ED45) from F1 - F3 were 71,01  0,39 %, 72,48  0,87 %, and 72,36  1,97 %. Analysis statistic of Anova indicated that there was no significant different of ED45. The result suggested that formula with 3% polyplasdone XL-10 provided optimal physical characteristics and dissolution rate of piroxicam Orally Disintegrating Tablet. Keyword : Orally Disintegrating Tablet, Piroxicam, Polyplasdone XL-10, Physical Characteristics, Dissolution Rate, Dissolution Efficiency.