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American Heart Association Texas Affiliate

American Heart Association Texas Affiliate. Brent Fields Vice President Research Administration & State Health Alliances. Research AHA Top Priority. The AHA believes that learning more about the #1 and #3 killers in America is one of the best ways to accomplish our mission:

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American Heart Association Texas Affiliate

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  1. American Heart AssociationTexas Affiliate Brent Fields Vice President Research Administration & State Health Alliances

  2. Research AHA Top Priority The AHA believes that learning more about the #1 and #3 killers in America is one of the best ways to accomplish our mission: Impact Goal: By 2010, we will reduce coronary heart disease, stroke and risk by 25 percent.

  3. The AHA’s commitment to research is reflected in our strategic plan: • Increasing the capacity of the research community to generate the highest quality research; • Identifying critical research agendas and increasing the understanding of specific cardiovascular issues.

  4. Research ExpenseforMajor National Health Agencies: 2004 A American Cancer Society B Alzheimer’s Association C American Diabetes Association D National Multiple Sclerosis Society E March of Dimes F Muscular Dystrophy Association G Juvenile Diabetes Association H American Heart Association

  5. AHA’s 2004-05 EXPENDITURES AHA National Budget Expenditures

  6. How each dollar is spent 75¢ 25¢ Donor Dollar National Center Texas Affiliate 15¢ 13.5¢ Research Allocation 28.5%

  7. Nobel Prize Recipients funded by AHA • 1937 – Dr. Albert Szent-Gyorgyi • 1971 – Dr. Earl Sutherland • 1985 – Dr. Joseph Goldstein • 1985 – Dr. Michael Brown • 1992 – Dr. Edwin Krebs • 1998 – Dr. Robert Furchgott • 2003 – Dr. Peter Agre

  8. Milestones 1956 - Dr. Ancel Keys, supported by funding from the Minnesota Affiliate, first links dietary fat with cholesterol. This discovery spurs the AHA to assume a leading role in urging Americans to change their eating habits. 1956 - Dr. Paul Zoll, aided by the Massachusetts Affiliate, publishes the first report of the successful ending of ventricular fibrillation in humans by externally applied countershock. 1957 - Dr. William Wierich, assisted by support from the Minnesota Affiliate and joined by Drs. Vincent Gott and Walter Lillehei, implants the first externally powered pacemaker in a patient with a surgical heart blockage. 1960 - Dr. Albert Starr performs the first long-term successful mitral valve replacement with a caged ball valve, ushering in a new era of valve replacement. He was supported in developing the artificial heart valve by the Oregon Affiliate and assisted by engineer Lowell Edwards. 1961 - Dr. Julius Jacobsen, with funding from the Vermont Affiliate, begins performing surgery with the aid of a microscope. Microsurgery ultimately leads to changes in coronary artery surgery, plastic surgery, neurosurgery, gynecology, limb reimplantation, and orthopedic and tumor surgery. 1985 - Drs. Joseph Goldstein and Michael Brown, sponsored by the AHA in 1972, 1973 and 1975, are awarded the Nobel Prize in Physiology or Medicine for their research on the role of low- density lipoprotein receptors in controlling blood cholesterol levels. Their research provides new insights into the ways fatty cholesterol enters body cells and why cholesterol levels may become too high.

  9. Texas Research Statistics • FY 06-07 there are currently 154 Texas Researchers funded by the AHA (TX Affiliate = 96; National = 58) • FY 06-07 total amount funded =$9,152,708 (TX Affiliate = $4,974,265; National = $4,178,443) • 2000-2008 total funding = $67,993,077 (TX Affiliate = $36,611,162; National $31,381,915) • Currently 11 cities and 22 institutions are represented by funded researchers in Texas • 100+ Texas researchers participated in our TXA Peer Review in 2006 • There are currently 15 Research Allocations and Advisory Committee Members (RAAC)

  10. Galveston Statistics • University of Texas Medical Branch • TXA Applications received/funded for the 2006 cycle = 13/2 • TXA Applications received/funded 2000-2006 = 100/19 • 7 Active Researchers = TXA - 6; National – 1 • 410,500 in Active AHA grants (FY 06-07 actual spent) (TXA - $345,500; National - $65,000) • $3,728,376 in AHA funding (2000-2008 allocated) (TXA - $2,355,981; National - $1,372,395) Current Research Allocations & Advisory Committee Members Paul Boor, MD – Professor, Dept. of Pathology

  11. Galveston Statistics University of Texas Medical Branch Texas Affiliate – Currently Funded Researchers 2005-07 Kishor Bhakat, PhD Beginning Grant-in-Aid Role of Human AP-endonuclease (APT1/Ref-1) in Regulation of Blood Pressure 2005-07 Perenlei Enkhbaatar, MD, PhD Beginning Grant-in-Aid Role of nitric oxide in pathogenesis of cardiopulmonary derangements in sepsis induced by smoke inhalation and pnemonia 2005-07 Luis Ruess, MD Grant-in-Aid Architecture of the Pore of Connexin43 Channels and Hemichannels 2005-07 Bruns Watts lll, PhD Beginning Grant in Aid Regulation of Renal Transport by Neurotropins 2006-08 Michael Kinsky, PhD Beginning Grant in Aid Pharmacologic Modulation of Fluid Therapy 2006-08 Sutapa Ray, PhD Beginning Grant in Aid STAT3 Signaling in Acute Phase Response

  12. Galveston Statistics University of Texas Medical Branch National Center – Currently Funded Researchers 2006-09 Sanjeev Choudhary, PhD Scientist Development Grant Novel Role of the NF-kB inducing kinase in Respiratory Syncytial Virus infection

  13. Research Focus • Training and career development of beginning scientists • Support of cutting edge basic and clinical science

  14. What Kinds of Research Do We Support? The AHA supports research that is broadly related to the cardiovascular area and stroke.

  15. Basic Cell and Molecular Biology Behavior Science, Epidemiology & Prevention Bioengineering & Biotechnology Brain Cardiac Biology/Regulation Cardiac Electrophysiology & Arrhythmias/Regulation Cardiorenal Cardiovascular Development Cell Transort, Physiology & Metabolism Immunology and Microbiology Liporproteins, Lipid Metabolism & Nutrition Lung, Respiration & Resuscitation SCIENCE AREAS

  16. Molecular Signaling Radiology & Imaging Surgery Thrombosis Vascular Biology & Blood Pressure/Regulation Vascular Wall Biology SCIENCE AREAS

  17. Programs Offered by AHA National Center • Scientist Development Grant January and July Application Deadline for January and July activation • Fellow to Faculty Grant January and July Application Deadline for January and July activation • Established Investigator Award July Application Deadline for January activation

  18. Programs Offered by the Texas Affiliate • Postdoctoral Fellowship January application deadline for July activation • Beginning Grant-in-Aid January application deadline for July activation • Grant-in-Aid January application deadline for July activation

  19. Postdoctoral FellowshipTo provide stipend support to help trainees initiate careers in cardiovascular and stroke research, and further research training while obtaining significant research results.(2006 Success Rate for this Program: 51 Applications, 8 funded, 16% funded) Deadline: January 4, 2007 Award: $30,000 - $46,000 stipend, depending on years of training or experience, plus annual $3,000 departmental allowance.  Term: 1 or 2 years. May apply for competitive one-year award. • Full-time research effort and sincere interest in pursuing a career in cardiovascular related research expected. • Applicant must hold a doctoral degree and have less than 6 years of post doctoral research training and experience at award activation (July 1, 2007). • Support is limited to work within non-profit institutions in Texas. • Institutional supplementation permissible under certain conditions. • An investigator may sponsor no more than two Affiliate Post Doctoral Fellows at any one time. Any application for a new award that would exceed this limit will not be reviewed. • Each of the following criteria will be considered: • The applicant • The sponsor’s qualifications • The environment and training program resources • The specific research project

  20. Beginning Grant-in-aidTo Promote the Independent Status of Promising Beginning Scientists by Supporting High Quality, Well-defined Research Projects in the Cardiovascular Area, Including Stroke. (2006 Success Rate for this Program: 90 applications, 21 funded, 23% funded) Deadline: January 4, 2007 Award: $65,000 per year maximum, including 10% overhead. Up to $15,000 annually for PI salary, including fringe benefits. Term: 2 years. Competitive renewal is possible for up to four years of support. Applicants must have: • an MD, PhD, DO, DVM, or equivalent doctoral degree. • A faculty appointment or equivalent academic or research track position, up to • and including a rank of assistant professor, by the time of award activation (July 1, 2007). • The applicant must meet institutional requirements for submission of an extramural, peer • reviewed grant proposal. • No more than 7 years of active faculty appointment prior to award activation (July 1, 2007). • No more than $100,000 of all extramural grant support per year, excluding principal • investigator and collaborating investigators salaries, fringe, and intramural funding • Each of the following criteria will be considered: • Evidence the award will promote the independent status of the applicant • Scientific excellence of the proposal • Qualifications of the applicant, including relevant experience, familiarity with published work in the field and productivity • Adequacy of the available resources, including research facilities and institutional environment

  21. Grant-in-aidTo Support the Most Innovative and Meritorious Research Projects FromIndependent Investigators in the Cardiovascular Area, Including Stroke.(2006 Success Rate for this Program: 78 applications, 16 funded, 21% funded) Deadline: January 4, 2007 Award: $65,000 per year maximum, including 10% overhead. Up to $15,000 annually for PI salary, including fringe benefits.  Term: 2 years. (One year requests are exceptional, but allowed) Continuous support of any one investigator is limited to 4 years Applicants must have: • An MD, PhD, DO, DVM, or equivalent doctoral degree • A faculty appointment or equivalent academic or research track position, up to and including a rank of assistant professor, by the time of award activation (July 1, 2007). The applicant must meet institutional requirements for submission of an extramural, peer reviewed grant proposal. • No more than $200,000 of all extramural grant support per year, excluding principal investigator and collaborating investigators salaries, fringe, and intramural funding • Grants will not be awarded to supplement or duplicate any work that is being supported by other funding agencies. The only exceptions are career development awards. • The scientific merit – with emphasis on the innovative nature of the proposal – is the most important factor. Other Criteria include: • The presence of new or original ideas • Clear statement of research • Sufficient experimental detail in the research plan • Understanding of the essential methodology • Adequacy of the experimental design

  22. 2006Success Rate – Texas Affiliate Awards Funded = 45 ($5,314,314) 11 cities – 18 institutions (New 2006 Awards) (RAAC allocations from May, 2006 Committee Meeting)

  23. 2006 Success Rate – National Center Awards Funded = 22 ($7,500,000) 7 cities – 7 institutions (National allocations to Texas for January & July 2006)

  24. Western Review Consortium Texas Affiliate Consortium WSA Research Steering Research Committee Committee Committee Peer Review Committees (10) Peer Review Structure

  25. Peer Review Study Groups2006-07

  26. An idea begins Application submitted Assigned to reviewers Critique developed Research Committee Rank-ordered list Peer Review Committee $ Funded E-mail notification Research completed Reports Published Findings translated Life Cycle of a Research Application Hmm… Yea!

  27. The ProcessTexas Affiliate January February March • Application Deadline • Applications assigned to Committees • Committee Chairs review assignments • Committee Chairs finalize assignments • Reviewers input preference • Paper copies are sent to reviewers May April July • Research Committees meet • Award Notification • Peer Review Committee meets • Award activation • September: online applications are available • October: institutional tour to promote program

  28. Other AHA Scientific Products • AHA Professional Membership/Scientific Council • Scientific Statements/Guidelines • Scientific Sessions, Conferences and Workshops • AHA Scientific Journals • My.Americanheart.org

  29. QUESTIONS? For Assistance Contact: Brent Fields VP, Research Administration 512-433-7103 – Phone Rhonda Jennings Administrative Assistant, Research Administration 512-433-7108 – Phone 512-433-7260 – fax texresearch@heart.org

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