ABSTRACT

1. ABSTRACT THE INFLUENCE OF NIOSOME SYSTEM (SPAN 20CHOLESTEROL) ON PREPARATION CHARACTERISTICS AND RELEASE OF DICLOFENAC SODIUM FROM GEL CARBOPOL ETD 2020 Atika Rizkia Noviani The purpose of the present study was to determine the influence of niosome system that is formed by span 20 and cholesterol in molar comparation between sodium diclofenac, span 20, and cholesterol = 1 : 6 : 6 on preparation characteristic and release of diclofenac sodium from gel based carbopol ETD 2020. Formulation of diclofenac sodium gel was divided into three kinds of formula. Formula I, as a control, was a gel of diclofenac sodium in carbopol ETD 2020, formula II was a gel of diclofenac sodium with Span 20 and cholesterol addition but without preparation as a niosome, and formula III was a gel of diclofenac sodium that was prepared into niosome system. Assay of release was done by using diffusion cell and celofan membrane. Dissolution apparatus (paddle stirrer) was filled by phosphat buffer saline pH 7,4 ± 0,05 at temperature 37 ± 0,5°C. Release of diclofenac sodium from all formulation was shown by value of flux. And then it was analyzed by statistic programmed using one way analysis of variance. The result showed that there was a significant difference between formula I, formula II, and formula III. Flux of formula I was 154,0973 ± 12,03, formula II was 53,0260 ± 3,72, and formula III was 74,7947 ± 2,04. Flux of formula III was higher than formula II and formula I was the higher. The conclusion is niosome system that is formed by span 20 and cholesterol in molar comparation between sodium diclofenac, span 20, and cholesterol = 1 : 6 : 6 gives influence on preparation characteristic and release of diclofenac sodium from gel based carbopol ETD 2020. Keyword (s) : Niosome, diclofenac sodium, carbopol ETD 2020, release