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Creation of a standard biological part

Creation of a standard biological part. A. Project Overview. Caulobacter crescentus produces the strongest known biological adhesive – many times stronger than the gecko’s foot. We intend to create a standard biological part out of this adhesive.

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Creation of a standard biological part

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  1. Creation of a standard biological part A

  2. Project Overview • Caulobacter crescentus produces the strongest known biological adhesive – many times stronger than the gecko’s foot. • We intend to create a standard biological part out of this adhesive. • This will open many applications of synthetic biology…

  3. Background • Adhesive center – the “holdfast” – consists of a polysaccharide clump • Holdfast put in place by four regulatory proteins

  4. Research Areas • Isolate relevant holdfast DNA from the rest of the genome: • Holdfast location proteins HfaA-D • Polysaccharide synthesis proteins (unknown) • Determine the locating mechanism to adapt it for use anywhere in the cell. What factors cause the holdfast to locate on the stalk?

  5. 1. Holdfast Location Protein Sequences • The sequences for HfaA-D are already known. We will optimize the sequences for E. coli and incorporate them into the part.

  6. 2. Polysaccharide Synthesis Proteins • It is unknown how the polysaccharide holdfast is synthesized or what all its components are.

  7. 3. • []

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