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Laurea position at the Italian National Cancer Institute, Regina Elena (IRE)

Laurea position at the Italian National Cancer Institute, Regina Elena (IRE). Telomere regulation by miRNAs in cancer and ageing. Background:

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Laurea position at the Italian National Cancer Institute, Regina Elena (IRE)

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  1. Laurea position at the Italian National Cancer Institute, Regina Elena (IRE) Telomere regulation by miRNAs in cancer and ageing Background: Telomeres protect chromosome ends from DNA repair mechanism and are essential for cellular viability and genomic stability. The shortening of telomeres in adult cells provides a molecular mechanism for organismal ageing. Cancer cells are able to escape from “ageing” by the activation of telomerase, a reverse transcriptase that adds back and re-juvinates telomeres of cancer cells. Consequently tinhibiting telomerase or telomere control is a promissing aproach for cancer therapies. DNA-FISH detecting telomeres in human cells YOUR PROJECT: Telomeres are controlled by the balanced action of multiple proteins (shelterin, telomerase,..). You will for the first time identify miRNAs that control telomere function in cancer and aging and study the function of these “telo-miRNAs” in the context of cancer and ageing. Your aim will be to identify “telo- miRNAs with high relevance for future ncRNA based cancer therapies. You will use various methods such as DNA-FISH, miRNA technologies, cloning techniques, Immunocytochemistry, cell culture techniques to accomplish these goals. THE INSTITUTE: The Italian National Cancer Institute, Regina Elena offers an open, modern scientific atmosphere and state of the art equipments such as Illumina deep sequencing, mass spectroscopy and array platforms For contact: Stefan Schoeftner, PhD E-mail: schoeftner@ifo.it Telomeres and ncRNA group Department for Molecular Medicine Italian National Cancer Institute, Regina Elena (IRE) Via Elio Chianesi 53, Rome References: Schoeftner et al. Telomere shortening relaxes X chromosome-inactivatio and affects global genome transcription. PNAS, 2009 Schoeftner S and Blasco MA. A “higher order” of telomere regulation: telomere heterochromatin and telomeric RNAs. EMBO J. 2009 Schoeftner S. and Blasco MA. Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II. Nat. Cell Biol. 2008

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