Sanjiv Bachal & Alok Pandit Equinox Software & Services Private Limited Dec 2013

1. Sanjiv Bachal & Alok Pandit Equinox Software & Services Private Limited Dec 2013 Potential Environmental Impact (PEI) Assessment of Solvent Recovery System Using Waste Reduction Algorithm (WAR)

2. Agenda • Introducing Equinox • The importance of solvents • Process design of Solvent Recovery system • Waste Reduction Algorithm (WAR) • Case studies • Conclusion • Vote of Thanks

3. EQUINOX Improving process and plants performance globally Through IT-catalyzed Chemical Engineering

4. Our Mantra “…Gain better“process” understanding to“process”better Gains…” 4

5. A New Kind Of Process Company Broad Base of Customers • Model Based Process Consulting, Process IT Solutions & Services • Among the largest # Software platform independent companies in its chosen business areas for CPI/HPI/Pharma • India based company in active business since 2007 • Successful Delivery of 100+ projects • 50+ customers in 10 countries in 3 continents • Novel Application Solutions deployed thru internal R&D • Profitable growth, based on internal funds

6. Now in its 7th year… Incorporated in 2005 Operational in 2007 Clocked a CAGR of 60% over last five years Global customers in UAE, Malaysia, Qatar, Saudi Arabia, Italy, India, USA, Thailand, Netherlands Member – NASSCOM, FICCI, MCCIA Consistent repeat business – A sign of customer’s trust. Delivered 100,000+ Hours of Consulting in last 18 months Strategic Alliances with world leaders – FRI and OLI

7. Why solvents are needed: Solubilizing the reactants Facilitate reaction Facilitate heat transfer/control Purification Solvents constitutetypically 80-90 wt% of the process mass Contribute about 15-25 % to the cost of manufacturing of Active ingredient Number of solvents used in an API unit could be anywhere in the range of 10-50 Number of used solvent streams could be > 100 Importance of Solvents

8. Binary solvent mixtures are a rare occurrence – multi-component systems are common Multi-step separation processes with multiple permutations and combinations of distillation train Process Design Challenges

9. Methodologies followed in Industries for design of solvent recovery system: Experience/Operation wisdom Consultants Commercial Simulators etc Process Design - Engineering Practices

10. MAXSOL – The complete science driven product/Application to maximize solvent recovery Considers various aspects in process Designing: Thermodynamics Operation Hardware Economics Environment Process Design - Engineering Practices

11. The Green/Environment Aspect: The Environment Impact Assessment (EIA) of the Design Alternatives Design of Solvent Recovery Systems

12. What is Waste Reduction Algorithm (WAR): Algorithm developed by US EPA to evaluate environmental impacts of process design How it works By evaluating processes in terms of their potential environment impacts (PEI) What is PEI Effect a chemical would have on the environment if it were simply emitted into the environment EIA - Waste Reduction Algorithm

13. PEI categories considered in the Waste Reduction Algorithm (WAR): Toxicological Human Toxicity Potential by Ingestion (HTPI) Human Toxicity Potential by Exposure (HTPE) Aquatic Toxicity Potential (ATP) Terrestrial Toxicity Potential (TTP) Global Global Warming Potential (GWP) Ozone Depletion Potential (ODP) Photochemical oxidation or Smog Formation Potential (PCOP) Acidification or Acid-Rain Potential (AP) EIA - Waste Reduction Algorithm

14. EIA - Waste Reduction Algorithm PEI Analysis Envelope PEIout PEIout MASS MASS Energy Generation Process Recovery Process Waste Energy Energy Waste Energy MASS MASS PEIin PEIin

15. A case study is discussed here to highlight the application of WAR algorithm to understand the PEI of various design alternatives for an actual solvent mixture separation MDC – THF – Water System EIA - Waste Reduction Algorithm

16. New Design - Option 1 Waste Reuse Waste Reuse

17. New Design - Option 2 Reuse Waste Waste Reuse

18. External Environment Efficiency of the process Total Rate PEI Analysis Using WAR • The contribution due toPCOP is predominant in both the options • Option 2 PEI is marginally better due to lower contribution of PCOP category

19. External Environment Efficiency of the process Rate per kg of product PEI Analysis Using WAR • Option 1 shows a better performance per kg of product – Option 1 has higher product yield compared to Option 2

20. Internal Environment Efficiency of the process Total rate of PEI generation PEI Analysis Using WAR

21. Internal Environment Efficiency of the process Generation per kg of product PEI Analysis Using WAR

22. PEI Generation - Energy Usage Environmental Energy efficiency of the process PEI Analysis Using WAR

23. Simple and technically sound assessment of environmental impact of process design alternatives Equinox has developed MAXSOL with proven track record to handle new design and revamp of solvent recovery system Key Take-Aways

24. Contact Information Contact: Dr. Sanjiv Bachal Phone: +91-20-41020122 Email: sanjiv.bachal@equinoxweb.co.in Website:www.equinoxweb.co.in