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This study aims to characterize the histologic development of osteoarthritis (OA) in a mouse model and minimize surgical trauma through a minimally invasive approach. The goal is to achieve faster recovery and early weight bearing for the mice.
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Minimally Invasive Destabilization of Medial Meniscus (DMM) Osteoarthritis Mouse Model Dr. Anirudh Sharma M.B.B.S., M.S. (Orthopaedics)
Aims • Characterize histologic development of OA • Minimize surgical trauma • Faster recovery & early weight bearing
Rationale • Mimic human conditions • Eliminate confounders related to extensive surgical exposure • Decrease operative time
Method • Surface mark entry portal • 1 mm x 1 mm (length x depth) incision • Curette IFP and locate MM • Identify MMTL & incise under direct vision • Wash and closure (single suture/tissue adhesive)
Results • Waiting for histology slides and scoring.