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Minimally Invasive Destabilization of M edial Meniscus (DMM ) Osteoarthritis Mouse Model

This study aims to characterize the histologic development of osteoarthritis (OA) in a mouse model and minimize surgical trauma through a minimally invasive approach. The goal is to achieve faster recovery and early weight bearing for the mice.

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Minimally Invasive Destabilization of M edial Meniscus (DMM ) Osteoarthritis Mouse Model

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  1. Minimally Invasive Destabilization of Medial Meniscus (DMM) Osteoarthritis Mouse Model Dr. Anirudh Sharma M.B.B.S., M.S. (Orthopaedics)

  2. Aims • Characterize histologic development of OA • Minimize surgical trauma • Faster recovery & early weight bearing

  3. Rationale • Mimic human conditions • Eliminate confounders related to extensive surgical exposure • Decrease operative time

  4. Method • Surface mark entry portal • 1 mm x 1 mm (length x depth) incision • Curette IFP and locate MM • Identify MMTL & incise under direct vision • Wash and closure (single suture/tissue adhesive)

  5. Images

  6. Results • Waiting for histology slides and scoring.

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