slow degrading

1. Adaptable biomaterials that enable cell-induced remodeling and drug deliverySarah C. Heilshorn, Stanford University, DMR 0846363 Drugs are only active within certain concentration ranges and at specific locations in the body. This can make it very difficult to target specific organs (such as the brain) with the appropriate drug concentration. This problem becomes more complex if multiple drugs need to be delivered. In response, we have engineered a new gel matrix that can release several drugs at distinct locations and times with precise concentration control. The matrix is biodegradable and adsorbs into the body after use. We are investigating use of this matrix to deliver neuroprotective peptide drugs. Non-degrading matrix slow degrading fast degrading fast release Model “Drug” Release (%) slow release 1 mm 1 mm 0 days 7 days Straley K, Heilshorn SC. Advanced Materials. 2009, 21:4148.

2. Adaptable biomaterials that enable cell-induced remodeling and drug deliverySarah C. Heilshorn, Stanford University, DMR 0846363 This summer, the laboratory hosted two high school students from under-represented minority groups. With the guidance of a graduate student mentor, the high school students performed independent research projects and prepared posters describing their results. Both students are interested in pursuing science or engineering and would be the first of their families to attend college. We have continued to informally mentor the students throughout the school year. High school intern (center) presenting her poster with her graduate student mentor (L) and Prof. Heilshorn (R). Through DMR support, graduate student Nicole Romano was selected as a US representative to attend a meeting of Nobel Laureates in Lindau, Germany. Nicole presented highlights of her inspiring trip to other students after she returned to the US. Nicole Romano and Nobel Laureate Jack Szostak.