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Understanding Sarcomere Function in Muscle Contraction

Explore the intricacies of sarcomeres, the functional units of skeletal muscle, including the organization of myofilaments, the role of titin in muscle elasticity, and the energetics of troponin interaction. Learn about the regulation of calcium ions in muscle contraction and the process of excitation-contraction coupling.

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Understanding Sarcomere Function in Muscle Contraction

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  1. Muscle Types and Their Characteristics

  2. Skeletal Muscle Anatomy

  3. Muscle Fiber Anatomy

  4. Anchoring the Myofilaments

  5. Sarcomere Banding

  6. Contractionin a Sarcomere

  7. Thin and Thick Filaments of the Sarcomere

  8. Titin https://en.wikipedia.org • Runs between Z lines and M line. • Helps organize sarcomere and limits length change or at least contributes to stiffness of resting sarcomeres. • Important elastic component of muscles. https://en.wikipedia.org

  9. Actin

  10. Thin Filament Side View

  11. Thin and Thick Filament Interaction

  12. Energetics of Troponin

  13. More on the Organization of the Thin Filament

  14. Attachment of Thin Filaments to Z-Lines

  15. A Schematic of Myosin

  16. Myosin Dimer

  17. "Polarity of the Thick Filaments"

  18. Polarity of the Myosin Power Stroke

  19. Arrangement of Myosin Heads Around a Thick Filament

  20. Linked Allosteric Forms of a Protein

  21. The Crossbridge Cycle Let's start here (relaxed muscle)

  22. Energy and Entropy Entropic systems change state randomly such that the macrostate remains the same. Organized systems change state in a decided direction (essentially the useful work of the system); "energy" input is what provide directionality.

  23. Ca++ Regulation at the SR

  24. Calsequestrin as a Ca++ Buffer

  25. Relative Binding Affinities of the SR-bound Ca++ Pump vs. Thin Filament Bound Troponin

  26. Ca++ and Binding to Troponin

  27. Questions: How is Thin Filament Regulation Organized? What has a greater potential activity -- Ca++ gates or Ca++ ATPase? What has a greater affinity -- the Ca++ ATPase or the calmodulin (troponin C)?

  28. Excitation-Contraction Coupling EC coupling is defined as the events that link a nervous system command (both contract and relax) to the mechanical events of muscle contraction.

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