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This study investigates the impact of gene knockout on body weight, vision, and sensory responses in mice. Results show differences in various parameters between WT and KO mice, shedding light on potential implications.
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WT WT WT KO KO KO Supplementary Figure 1 A Body weight B Vision C Electroretinogram D Open field Rotarod E p=0.34 400 WT WT 17.5 75 KO KO 15.0 300 WT 12.5 50 KO Body weight [g] Preference [%] Amplitude (μV) Time [s] 10.0 Amplitude [μV] 200 7.5 25 5.0 100 p=0.027 2.5 0 0.0 0 WT KO WT KO Periphery Intermediate Center Time [ms] Olfaction G Pain sensation H Hearing I Motivation J Prepulse inhibition F Startle 100 100 300 4 20 80 3 15 80 200 60 Sucrose consumption [%] 2 Inhibition [%] 10 Startle amplitude [au] Latency to find food [s] Latency [s] 40 60 100 1 5 20 0 0 0 40 0 60 80 1 2 3 4 70 75 80 100 120 KO WT KO WT dB Days dB
Supplementary Figure 2 WT WT KO KO C Open field D Open field E Open field F Vision G Olfaction 300 200 75 p=0.037 400 25 150 20 300 200 15 Preference [%] 100 50 200 Latency to periphery [s] Velocity [mm/s] Time [s] Latency to find food [s] 10 100 50 100 5 0 0 0 25 0 Periphery Intermediate Center WT KO WT KO WT KO WT KO B A Basic EPM EPM in darkness WT 300 300 KO p=0.03 p=0.0002 200 200 Time [s] Time [s] 100 100 0 0 Closed Center Open Closed Center Open
