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PKMzeta and Memory

PKMzeta and Memory. Manhasset Science Research Paris Thatos. Need. Long-term trend in acute drug-related deaths, 1985 - 2004. Percentage of People Experiencing a Mental Disorder in their Lives. (Gotz, 2004). (Gallaher, 2007). Long Term Potentiation.

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PKMzeta and Memory

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  1. PKMzeta and Memory Manhasset Science Research Paris Thatos

  2. Need Long-term trend in acute drug-related deaths, 1985 - 2004 Percentage of People Experiencing a Mental Disorder in their Lives (Gotz, 2004) (Gallaher, 2007)

  3. Long Term Potentiation • The complex chemical processes that form long-term memories (Cook, 2006) • Many proteins are involved in LTP, specifically PKMzeta (Kanehisa, 1999)

  4. PKMζ (Protein Kinase M-Zeta) • Responsible for maintaining long-term potentiation (Ling, 2002) • The workings of PKMzeta are known to be disrupted by a peptide labeled ZIP (zeta inhibitory peptide)

  5. Literature Review • Peter Serano, Todd C. Sacktor • Used ZIP • Rats treated with ZIP forgot how to perform the water maze. (Morris, 2004)

  6. Do-ability • Model Organisms that incorporate PKMzeta include -Drosophila -Octopi -Aplysia

  7. Bibliography • Olton, D.S., & Samuelson, R.J. (1976). Remembrance of places passed: Spatial memory in rats. Journal of Experimental Psychology: Animal Behavior Processes, 2, 97-116. • Ling D, Benardo L, Serrano P, Blace N, Kelly M, Crary J, Sacktor T (2002). "Protein kinase Mzeta is necessary and sufficient for LTP maintenance". Nat. Neurosci.5 (4): 295-6. • Serrano P, Yao Y, Sacktor T (2005). "Persistent phosphorylation by protein kinase Mzeta maintains late-phase long-term potentiation". J Neurosci25 (8): 1979-84. • Pastalkova E, Serrano P, Pinkhasova D, Wallace E, Fenton A, Sacktor T (2006). "Storage of spatial information by the maintenance mechanism of LTP". Science313 (5790): 1141-4 • Cooke SF, Bliss TV (2006). "Plasticity in the human central nervous system". Brain129 (Pt 7): 1659-73 • Boron, Walter F. (2005). Medical Physiology: A Cellular And Molecular Approach. Elsevier/Saunder • Clugnet, MC; LeDoux JE (01 Aug 1990). "Synaptic plasticity in fear conditioning circuits: induction of LTP in the lateral nucleus of the amygdala by stimulation of the medial geniculate body." (PDF). J Neurosci10 (8): 2818-24. • Sweatt J (1999). "Toward a molecular explanation for long-term potentiation". Learn Mem6 (5): 399-416.

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