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William Bullock, PhD Research Business Operations

Ensuring That Lessons Learned Are Not Forgotten Leveraging ELN to Transform the Safety Paradigm. William Bullock, PhD Research Business Operations. Ramesh Durvasula, PhD Research Informatics & Automation. http://cen.acs.org/content/dam/cen/static/pdfs/ACSHazardAnalysis20130904.pdf.

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William Bullock, PhD Research Business Operations

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  1. Ensuring That Lessons Learned Are Not ForgottenLeveraging ELN to Transform the Safety Paradigm William Bullock, PhD Research Business Operations • Ramesh Durvasula, PhD • Research Informatics & Automation

  2. http://cen.acs.org/content/dam/cen/static/pdfs/ACSHazardAnalysis20130904.pdfhttp://cen.acs.org/content/dam/cen/static/pdfs/ACSHazardAnalysis20130904.pdf

  3. Agenda Case Study People or Process ? IT Requirements New Directions

  4. Sodium Trifluoroacetoxyborohydride United States Patent 4,835,278

  5. Sodium Trifluoroacetoxyborohydride Sodium borohydride

  6. Sodium Trifluoroacetoxyborohydride United States Patent 4,835,278 Trifluoro Acetic Acid NaBH4 NaBH(F3CCO2)3 THF Moderate Reducing Agent Very Mild Reducing Agent

  7. Sodium Trifluoroacetoxyborohydride United States Patent 4,835,278 Trifluoro Acetic Acid NaBH4 THF

  8. Sodium Trifluoroacetoxyborohydride Trifluoro Acetic Acid NaBH4 THF

  9. Sodium Trifluoroacetoxyborohydride • Exothermic Reaction • Byproduct: hydrogen gas • Powder dissolves rapidly, reaction not controlled, will consistently catch fire • Lesson: Must use pelletized NaBH4, dissolution controls reaction rate Trifluoro Acetic Acid NaBH4 THF

  10. Sodium Trifluoroacetoxyborohydride Same Incident Occurred Reaction Issue First Identified 2004 2005 2006 2007 2008 Communicated at Department Safety Briefing

  11. Other Lessons Requiring Re-Learning NaH Above ambient temperature can decompose violently DMF TFA Exceptionally cell penetrable Causes acid burns well in excess of acid strength POCl3 Quench requires vigorous stirring for > 15 min with ice, violent exotherm likely

  12. Challenge – How to Ensure Lessons are Learned by Everyone? Dilbert, 3/26/2006 Is the Problem the Chemist or the Process?

  13. The Three Factors: INFO, Time, Vehicle Material Safety Data Sheet vs. Actionable Information

  14. The Three Factors: Info, TIME, Vehicle When does chemist FETCHsafety info? Design The Reaction Procure The Materials Synthesize The product When does chemist NEEDsafety info?

  15. The Three Factors: Info, Time, VEHICLE Chemist Login Retrieve SharePoint MSDS System SharePoint Hardcopy Memory Divisional Best Prac Bretherick’s SOPs

  16. The Three Factors: Info, Time, VEHICLE From a fragmented pull to a UNIFIED PUSH Chemist Divisional Best Prac MSDS System Bretherick’s SOPs Memory

  17. Business Requirements • INFO, TIME, VEHICLE • Centralizing the lessons (i.e., business rules) • Turning “offline pull” into “timely PUSH” • High Specificity, Low False Warnings • Simplify the process for CURATING the Rules • Monitoring & alert mechanism for Safety Committee

  18. Electronic Lab Notebooks • Reagent calculator function drives consistent use for all reactions • The last IT interaction before chemist runs the experiment in the lab • ELN can be customized to deliver event-driven or data-driven triggers/messages

  19. Curating the Rules – SharePoint • Editable by Safety Committee • Tool for importing rules into ELN database

  20. Multiple Trigger Mechanisms • Single Hazardous Chemical • Hazardous Combinations of Chemicals • Large Scale of Reaction

  21. Excel  SharePoint  ELN

  22. Monitoring & Alerting for EHS/Safety Group

  23. Technical Implementation • Chemistry Safety section • Safety log table: stores the chemistry safety warning logs, and a section listener that prevents users from deleting/renaming the section. • User collection listeners • Has been added to enable adding the Chemistry Safety section to it at run time. • Chemistry Experiment collection listener • Captures the Collection Saving event, and performs chemistry safety check if necessary. • Reaction section listener • One section listener has been created on the Reaction section to accomplish two things. First, to capture the Show event of the reactant table to get the original list of reactants, and second, to capture the SectionAdding event to display the general chemistry safety warning before the reaction section being added.

  24. New Data Flow Chemistry Near Misses MSDS Research Chemistry Safety Committee ELN & SharePoint Chemical & Engineering News U.S. Chemical Safety Board EHS

  25. The Impact • Large Scale Reaction Notifications Up 300% • No incidents or near misses for the documented rules

  26. BioITWorld Best Practices 2012 http://www.bio-itworld.com/2012/04/25/bio-it-world-announces-winners-2012-best-practices-awards.html

  27. Roadmap: BMS Safety Data Flow • Multiple Sources for Collecting Rules • Multiple Destinations for Rules Enforcement ELN Pharm Dev Reagent Inventory Rules Repository Chemistry LIMS Safety Committees Biology Reporting & Analytics

  28. Industry-wide Collaboration? • Pre-competitive Collaboration for the benefit of the community Public Website

  29. THANK YOU william.bullock@bms.com andrew.nation@bms.com

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