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BIOACTIVE COMPOUNDS FROM TROPICAL FRUITS: DIMOCARPUS LONGAN Lour. AND

Elvira Hermawati a , Lia D. Juliawaty a , Kiyotaka Koyama b , Kaoru Kinoshita b , Miki Kazuhiko b , Kunio Takahashi b , Yana Maolana Syah a , Euis H. Hakim, *a. BIOACTIVE COMPOUNDS FROM TROPICAL FRUITS: DIMOCARPUS LONGAN Lour. AND GARCINIA MANGOSTANA Linn.

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BIOACTIVE COMPOUNDS FROM TROPICAL FRUITS: DIMOCARPUS LONGAN Lour. AND

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  1. Elvira Hermawatia, Lia D. Juliawatya, Kiyotaka Koyamab, Kaoru Kinoshitab, Miki Kazuhikob, Kunio Takahashib, Yana Maolana Syaha, Euis H. Hakim,*a BIOACTIVE COMPOUNDS FROM TROPICAL FRUITS: DIMOCARPUS LONGAN Lour. AND GARCINIA MANGOSTANA Linn. aNatural Product Research Group, Department of Chemistry, Institut Teknologi Bandung, Jalan Ganeca 10, Bandung 40132, Indonesia bDepartment of Pharmacognosy and Phytochemistry, Meiji Pharmaceutical University, Noshio 2-522-1, Kiyose-shi, Tokyo 204-8588, Japan

  2. Introduction • Garcinia mangostana species (Guttiferae) locally known as “manggis”  abdominal pain, diarrhea, dysentery, and chronic ulcer. • Dimocarpus longan (Sapindaceae) or “lengkeng”  stomachache, febrifuge, vermifuge, and tonicum. • The CHCl3 extract of G. mangostana and D. longan pericarpshowed high activity on HUVEC (Human umbilical vein endothelial cells) proliferation inhibitory assay with the same IC50 3.9 μg/mL. Dimocarpus longan Garcinia mangostana

  3. Garciniamangostana HUVEC (Human umbilical vein endothelial cells) proliferation inhibitory assay 8-Deoxygartanin (1) IC50 4.0 µg/ml γ-Mangostin (3) IC50 4.0 µg/ml Gartanin (2) IC50 10 µg/ml 9-Hydroxychalabaxanthone (6) IC50 2.2 µg/ml β-Mangostin (5) α-Mangostin (4) IC50 1.6 µg/ml IC50 <1.0 µg/ml

  4. Dimocarpuslongan a HUVEC (Human umbilical vein endothelial cells) proliferation inhibitory assay bBACE-1 inhibitory assay (anti Alzheimer) or 21-Hydroxy-8(26)- 14-onoceradien-3-one 3-Hydroxy-8(26)- 14-onoceradien-21-one 7,14(27)-Onoceradiene-3,21-dione (8) aIC50 5.9 µg/ml (7) aIC50 4.0 µg/ml bIC50 11.09 µM Lansionic acid (11) aIC50 3.1 µg/ml Spathulenol (12) Lansiolic acid (9) aIC50 8.1 µg/ml Lansioside C (10) bIC50 0.70 µM

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