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All you wanted to know about laboratory tests, but were afraid to ask. The informed patient meeting the laboratory director. Standardization & Traceability The problem. By Dietmar Stöckl ST T Consulting - 7 -. Reminder. We heard laboratory testing would be a good idea, but.
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All you wanted to know about laboratory tests, but were afraid to ask The informed patient meeting the laboratory director Standardization & Traceability The problem By Dietmar Stöckl STT Consulting - 7 -
Reminder We heard laboratory testing would be a good idea, but ... All you wanted to know about laboratory tests -7-
The “Buts” You are healthy in one Lab – but sick in another All you wanted to know about laboratory tests -7-
J Clin Endocrinol Metab 25 hydroxyvitamin D • “Vitamin D assays yield markedly differing results; whether an individual is found to have low or normal vitamin D status is a function of the laboratory used. If the medical community is to make progress in correcting widespread hypovitaminosis D, vitamin D measurement must be standardized” • Binkley N, et al. Assay variation confounds the diagnosis of hypovitaminosis D: A call for standardization. J Clin Endocrinol Metab 2004;89:3152–7. All you wanted to know about laboratory tests -7-
Kidney Int Parathyroid hormone • “It appears unethical that all the companies making different PTH assays could not meet and decide how to standardize and calibrate a consistent circulating PTH measurement. Many physicians are making huge efforts to keep their patients within the target values recommended by the NKF/K-DOQI; however, most of them are misinformed by their PTH measurement”. • Torres PU. The need for reliable serum parathyroid hormone measurements. Kidney Int 2006;70:240-3. All you wanted to know about laboratory tests -7-
J Clin Endocrinol Metab Testosterone • Widely used assay methods to measure serum testosterone suffer from a lack of accuracy and sensitivity, making it difficult for physicians to appropriately diagnose and treat androgen-related disorders in women, children, and men. The February 2007 issue of the Journal of Clinical Endocrinology & Metabolism calls for standardizing the methods by which these assays are validated. • http://www.endo-society.org/media/press/2007/ • EndocrinePositionStatementCallsStandardizedTestosteroneAssays.cfm • http://www.cdc.gov/nceh/dls/hormone_standardization.htm All you wanted to know about laboratory tests -7-
Standardization • Tip of the iceberg! • 25 hydroxyvitamin D • Parathyroid hormone • Testosterone • General problem • Steroid hormones • Thyroid hormones • Protein hormones • Glyoprotein hormones • Cardiac markers • Tumor markers • New markers (Cytokines, Growth factors) • >And so much more Nearly did'nt dare to come out again! No Titanic around? All you wanted to know about laboratory tests -7-
Reference intervals • Serum sodium reference interval • "Variation in reference intervals was not related • to analytical platforms". • "The major reason for variation was simply historical, with no scientific foundation". • >Not restricted to the UK! • http://www.pathologyharmony.co.uk/graphics/Pathology%20Harmony%20Newsletter%20July%202008.pdf • Serum magnesium reference interval • Dewitte K. In search of the reference interval of serum magnesium – The last case of Hercule Poirot [in Dutch]. • BVLT Tijdschrift 2000;27:169-73. • >Origin of the Tietz reference interval • could not been traced. All you wanted to know about laboratory tests -7-
I type ... ... what science is that!? It was'nt me who said it. All you wanted to know about laboratory tests -7-
The next visit Standardization & Traceability The solution That makes me curious! All you wanted to know about laboratory tests -7-