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Emile Zuckerkandl and Linus Pauling, "Evolutionary Divergence and Convergence in Proteins,"

Emile Zuckerkandl and Linus Pauling, "Evolutionary Divergence and Convergence in Proteins," in Evolving Genes and Proteins, eds. V. Bryson and H. Vogel (New York: Academic Press, 1965). pp. 97-166. Comparing Hemoglobin Sequences. “There may thus exist a Molecular Evolutionary Clock”

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Emile Zuckerkandl and Linus Pauling, "Evolutionary Divergence and Convergence in Proteins,"

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  1. Emile Zuckerkandl and Linus Pauling, "Evolutionary Divergence and Convergence in Proteins," in Evolving Genes and Proteins, eds. V. Bryson and H. Vogel (New York: Academic Press, 1965). pp. 97-166. Comparing Hemoglobin Sequences

  2. “There may thus exist a Molecular Evolutionary Clock” Zuckerkandl & Pauling (1965) Clock for paralogs Divergegence between alpha and beta Divergegence between beta and gamma A model of sequence divergence can be used to extract the duplication dates of the difference hemoglobin chains

  3. “There may thus exist a Molecular Evolutionary Clock” Zuckerkandl & Pauling (1965)

  4. Different ortholog clocks keep different times PBS Evolution Library (http://www.pbs.org/wgbh/evolution/library/)

  5. Different proteins evolve at different rates Most recent common ancestor between Man-horse Rate of change: AA changes per site per year

  6. -Hillis, et al, 1996

  7. Parsimony tree compared to UPGMA tree

  8. Neighbor Joining distance matrices

  9. Neighbor Joining Star Decomposition

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