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Cling- E. coli : Bacteria on target

Cling- E. coli : Bacteria on target. Harvard iGEM 2007 Ellenor Brown Stephanie Lo Alex Pickett Sammy Sambu. Kevin Shee Perry Tsai Shaunak Vankudre George Xu. The motivation. To develop a system for directing bacteria to a target of interest and effecting downstream activity.

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Cling- E. coli : Bacteria on target

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  1. Cling-E. coli :Bacteria on target Harvard iGEM 2007 Ellenor Brown Stephanie Lo Alex Pickett Sammy Sambu Kevin Shee Perry Tsai Shaunak Vankudre George Xu

  2. The motivation To develop a system for directing bacteria to a target of interest and effecting downstream activity • Bacterial targeting is necessary for spatially-specific activity in the body or in nature • Post-targeting activity and transmembranesignalling are the next step in engineering genetic circuits that interface extracellular and intracellular environments

  3. The vision:Bacterial targeting via membrane display

  4. The vision:Inter-cellular activation viaLux quorum-sensing

  5. The vision:Intra-cellular activation viaFec signal transduction

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