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Bentley, K. CS, UCL

Bentley, K. CS, UCL. Developing The Artificial Cytoskeleton: adaptation through morphogenesis in diatoms. Katie Bentley, Chris Clack: CS, UCL Eileen J. Cox: Botany, NHM. The Artificial Cytoskeleton: NIC – 10/11 Feb 2004 . Bentley, K. CS, UCL. Background

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Bentley, K. CS, UCL

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  1. Bentley, K. CS, UCL Developing The Artificial Cytoskeleton: adaptation through morphogenesis in diatoms Katie Bentley, Chris Clack: CS, UCL Eileen J. Cox: Botany, NHM The Artificial Cytoskeleton:NIC – 10/11 Feb 2004

  2. Bentley, K. CS, UCL • Background • Hand design of robots and artificial agents • - Bad idea ! • Interest in how well adapted forms in nature have occurred: • Evolution: evolutionary robotics, co- evolution… No geno-pheno mapping • Development: L-system, GRN… Multicellular, no life-time adaptation The Artificial Cytoskeleton:NIC – 10/11 Feb 2004

  3. Bentley, K. CS, UCL Background Look a level lower… How are unicells able to dynamically adapt? How can they produce complex morphologies? Can we harness this ability to produce Alife agents with adaptable morphologies? - Mechanism: cytoskeleton - Mechanism: cytoskeleton - YES ! The Artificial Cytoskeleton:NIC – 10/11 Feb 2004

  4. Bentley, K. CS, UCL • Cytoskeleton • STRUCTURAL:ACCESSORY: • Microfilaments (Actin) - Actin Binding Proteins (ABPs) • Microtubules (Tubulin) - Microtubule Binding Proteins (MAPs) • Intermediate filaments - Motor proteins • ATP ADP : fuel Regulated by [CA2+] The Artificial Cytoskeleton:NIC – 10/11 Feb 2004

  5. Bentley, K. CS, UCL • Cytoskeleton • Dynamic interaction of these elements is the • mechanism for… • Cell motility • Cell division • Cell Polarization… • Dynamic nature gives cells adaptive powers a vertebrate skeleton cannot allow • Structural system (dynamic) • Transport system (dynamic) The Artificial Cytoskeleton:NIC – 10/11 Feb 2004

  6. Bentley, K. CS, UCL • Artificial Cytoskeleton • Developed alongside biological experiments (Eileen) • Dynamical, spatial computational system (C/C++, OpenGL, GLUT, GLUI): • - swarm rather than CA • Structural proteins interact with concs of accessory proteins and ions in 3D voxel space. The Artificial Cytoskeleton:NIC – 10/11 Feb 2004

  7. Bentley, K. CS, UCL The Artificial Cytoskeleton:NIC – 10/11 Feb 2004

  8. Bentley, K. CS, UCL • Experiments • Diatom specific model additions… • AC interacts with plasmalemma, mitochondria and other organic material: • affects silica deposition… • Adaptation to osmotic stress • Adaptation to nutrient depletion… The Artificial Cytoskeleton:NIC – 10/11 Feb 2004

  9. Bentley, K. CS, UCL Experiments Based on theory and model in: Bentley, K. et al (2003). Nature's Batik: A Computer Evolution Model of Diatom Valve Morphogenesis.  Journal of Nanoscience and Nanotechnology. In Press. The Artificial Cytoskeleton:NIC – 10/11 Feb 2004

  10. Bentley, K. CS, UCL § The Artificial Cytoskeleton:NIC – 10/11 Feb 2004

  11. Bentley, K. CS, UCL The Artificial Cytoskeleton:NIC – 10/11 Feb 2004

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