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Introduction of Micro-mixer

Introduction of Micro-mixer. Lab on a chip. Mixing principles. Micro-scale. Micro-scale => laminar flow conditions => difficult to mix. Modes of Mixing. Split and recombine Serial segmentation Rotation Chaotic vortex Supply external energy Thermal

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Introduction of Micro-mixer

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  1. Introduction of Micro-mixer

  2. Lab on a chip

  3. Mixing principles

  4. Micro-scale • Micro-scale => laminar flow conditions => difficult to mix

  5. Modes of Mixing • Split and recombine • Serial segmentation • Rotation • Chaotic vortex • Supply external energy Thermal Acoustic Electro-somotic Mechanical Passive Active

  6. Mixing by diffusion

  7. Diffusive micro mixer - and gradient generator Whitesides G. et al, Langmuir, Vol. 16, No. 22, 2000, 8311-8316

  8. Laminated flow cell scanner Orwar O. et al Anal. Chem. 2002, 74, 6133-6138

  9. Laminated flow cell scanner- and decade gradient generator Orwar O. Et al Anal. Chem. 2005, 77, 3897-3903

  10. Distributive micromixing chip

  11. Chaotic advection micro mixers- 3D rotation of the laminated flows Nuguyen N-T., Fundamentals and applications of microfluidics

  12. Chaotic advection serpentine mixer -3D rotation of the laminated flows - BEEBE D. et al. JOURNAL OF MICROELECTROMECHANICAL SYSTEMS, VOL. 9, NO. 2, JUNE 2000

  13. Chaotic advection in serpentine mixer

  14. Chaotic advection mixing -grooved channel bottom- G.M. Whitesides et al SCIENCE VOL 295 25 JANUARY 2002 647

  15. Chaotic advection mixing -patterned channel bottom- Nuguyen N-T., Fundamentals and applications of microfluidics

  16. Chaotic advection mixing- periodic herring bone pattern - G.M. Whitesides et al SCIENCE VOL 295 25 JANUARY 2002 647

  17. Chaotic advection mixing -periodic herring bone pattern-

  18. Dispersion properties of herringbone mixer Straight Herringbone G.M. Whitesides et al Science Vol 295 25 Jan. 2002 647

  19. Serially segmented chaotic mixer P. Tableing et al Physical Review E 72, 056312, 2005

  20. Multilamination mixing Jensen K F. et al, Ind. Eng. Chem. Res., Vol. 44, No. 8, 2005

  21. Multilamination mixingand alkaline hydrolysis of methyl formate

  22. Multiphase mixing

  23. Semented flow mixing - gas/fluid - Jensen KF. et al Langmuir, Vol. 21, No. 4, 2005

  24. Re-Pe diagram Pe - inertia (advection) in relation to diffusion Re - inertia (advection) in relation to viscous effects(laminar)

  25. HydrodynamicFocusing On the order of 30 nm in the extreme cases TO MIX IN TENS OF MICROSECONDS Austin et al, PRL (2002)

  26. Circular micromixing

  27. Circular mixer Circular micromixer Quake, Scherer (2001)

  28. In chaotic regimes, two close particles separate exponentially In confined systems, this property is extremely favorable to mixing,

  29. From Ottino’s book : « Chaotic Advection »

  30. Thermal mixer Thermal actuator Micromixer J. Evans, D. Liepmann, D., and A.P. Pisano, 1997, “Planar Laminar Mixer,” Proceeding of the IEEE 10th Annual Workshop of Micro Electro Mechanical Systems (MEMS ’97), Nagoya, Japan, Jan, pp.96-101.

  31. Time periodic transverse flow Main Flow Advection mixer Fluid A V time -V Fluid B 400 mm investigated by Y.K. Lee, C.M.Ho (1999), Mezic et al (1999)

  32. U U Perturbation is applied Line is stretched U Perturbation is stopped Line is folded

  33. actuation channel Glass slide Working channel Micro-valve 25mm 200mm Microvalve 1mm

  34. Actuation pressure (bar) Frequency (Hz)

  35. An efficient particle sorter, using resonance RESONANCES MAY BE USED TO SORT PARTICLES : BY CHANGING THE FREQUENCY OF THE PERTURBATION, ONE OBTAINS A SYSTEM WHICH MIXES FLUIDS, FILTERS PARTICLES, OR SIMPLY TRANSPORTS MATERIALS SIDE BY SIDE.

  36. A.Dodge, P. Tabeling, A. Hountoundji, M.C.Jullien (2004)

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