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Cohort Studies

Cohort Studies. Recruit cohort  sub-divide cohort into exposed and non-exposed sub-cohorts.  follow individual over time. Cohort Study: C yto M egalo V irus and Resten osis. 21. 28. 49. 2. 24. 26. 75. Risk in the exposed group. Risk in the non-exposed group.

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Cohort Studies

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  1. Cohort Studies Recruit cohort  sub-divide cohort into exposed and non-exposed sub-cohorts  follow individual over time Cohort & Case-Control Basics

  2. Cohort Study: CytoMegaloVirus and Restenosis 21 28 49 2 24 26 75 Risk in the exposed group Risk in the non-exposed group Cohort & Case-Control Basics

  3. Cohort Study: CytoMegaloVirus and Restenosis 21 28 49 2 24 26 = CMV+ group had 5.57 times the risk as CMV- group Can be converted to a “relative risk difference” (RRD) for discussion Cohort & Case-Control Basics

  4. Cohort Study: CytoMegaloVirus and Restenosis 21 28 49 2 24 26 “Excess risk” on an absolute scale Cohort & Case-Control Basics

  5. Cohort Study: CytoMegaloVirus and Restenosis 21 28 49 2 24 26 Attributable fraction in exposed cases Prop of cases that are exposed Attributable fraction in population Cohort & Case-Control Basics

  6. Case-Control Studies Identify all cases and [small number] non-cases  ascertain exposure history of cases and non-cases Cohort & Case-Control Basics

  7. Case-Control: Grilled meat and Pancreatic Cancer 53 53 ?? 85 43 ?? 168 96 96 Interpret just like an RR Cohort & Case-Control Basics

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