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Grand Challenges for Nanomedicine and Nanobiology Workshop Houston, Texas August 27 th , 2007

Grand Challenges for Nanomedicine and Nanobiology Workshop Houston, Texas August 27 th , 2007. Personal Thoughts. Targeted Delivery (Timing) EPR Tumor vasculature Potential for clinical impact versus clinical translation Diagnostics and Nanotechnology? Training and Team Science

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Grand Challenges for Nanomedicine and Nanobiology Workshop Houston, Texas August 27 th , 2007

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  1. Grand Challenges for Nanomedicine and Nanobiology Workshop Houston, Texas August 27th, 2007

  2. Personal Thoughts • Targeted Delivery (Timing) • EPR • Tumor vasculature • Potential for clinical impact versus clinical translation • Diagnostics and Nanotechnology? • Training and Team Science • Multi-PI R01s • NIH Pathway to Independence Award (K99/R00) • Mentored Research Scientist Development Award (K01) • Mentored Clinical Scientist Development Award (K08) • Clinical Oncology Training Grants (K12)

  3. Upcoming Sessions Nano Tutorial Sessions: Oct 16th, 2007 • Tutorial Session 1: Cells, Tissues, and Organs: Basic Principles of Functional Histology and Pathology • Tutorial Session 2: Basic Cancer Biology • Tutorial Session 3: Animal Models • Tutorial Session 4: Biodistribution of Nanoparticles • Tutorial Session 5: Materials Science/Nanotechnology • Clinical Pathway • Clinical trial grants and contracts • FDA • Nanotechnology Characterization Lab ASCB Special Session: Dec 1st, 2007

  4. Upcoming NIH Funding Opportunities • Nanoscience and Nanotechnology in Biology and Medicine (R01&R21), Oct. 22nd, 2007 • Biology of Breast Pre-Malignancies (R01), Nov. 17th, 2007 • RFA-CA-07-047 • insufficient understanding of normal and pre-cancer biology

  5. Upcoming NCI Funding Opportunities • SBIR Solicitation (PHS-2008-1), Nov. 5th, 2007 • Topic 241: Multifunctional Therapeutics Based on Nanotechnology • Topic 252: Nanotechnology Imaging and Sensing Platforms for Improved Diagnosis of Cancer • Multidisciplinary Development and Training in Cancer Nanotechnology Award (F32/F33), TBA • Innovative Molecular Analysis Technologies [IMAT] (R21/R33), Sept. 27th, 2007 • Innovative Technologies for the Molecular Analysis of Cancer: RFA-CA-07-033 • Application of Emerging Technologies for Cancer Research: RFA-CA-07-035 nano.cancer.gov

  6. Nanotechnology Characterization Lab (NCL)Role and Updates In Vitro In Vivo Physicochemical • The NCL developed and standardized analytical cascade that tests the pre-clinical toxicology, pharmacology, and efficacy of nanoparticles and devices. • Next submission date (9/1/2007 and 12/1/2007)

  7. NCL in vivoCharacterization Assays Plasma Profile • Initial disposition study • Tissue Distribution • Clearance • Half-life • Systemic exposure (plasma AUC)   • Immunotoxicity • 28 day screen • Immunogenicity (repeat-dose tox study)    • Dose -Range Finding Toxicity • Blood Chemistry • Hematology • Histopathology • Gross Pathology • GLP Studies • PK/ADME • Expanded Single Dose Acute Tox Organ Weights Main Study Hematology Interim Study

  8. Current NCL Collaborators

  9. Onsite Program Contacts • Larry Nagahara, Ph.D.Nanotechnology Projects Manager • Email:  nagaharl@mail.nih.gov • Jerry Lee, Ph.D. • Tech. Dev. Program Officer • Email: leejerry@mail.nih.gov

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