Nanomedicine and Nanobiology Research and CBET Nanomedicine Workshop August 27, 2007

1. Nanomedicine and Nanobiology Research and CBETNanomedicine WorkshopAugust 27, 2007 Judy Raper Division Director, Chemical, Bioengineering, Environmental & Transport Systems

2. OUTLINE • NSF, ENG and External Forces • CBET Organization • Budget and Trends • Nanomedicine and Nanobiology Research • Funding Opportunities • Questions

3. NSF, ENG & EXTERNAL FORCES

4. National Research Funding

5. NSF Twenty Year Budget by Accountin Millions of Current Dollars

6. American Competitiveness Initiative • The centerpiece of American Competitiveness Initiative (ACI) is to double the federal investment in key agencies that support basic research in physical sciences and engineering. • Over the next 10 years, the Federal agencies impacted are NSF, DOE Science, and NIST. • ACI includes three broad components: • Research in physical sciences and engineering (including 12 specific goals with 7 related to NSF) • Research and Development tax incentives • Education and workforce

7. American Competitiveness InitiativeFY 2007 – FY 2016 Source: OSTP, Feb. 2006

8. CBET Organization

9. CBET Vision and Mission • VISION • CBET will be a global leader in identifying and enabling the most innovative research and education at the frontiers of engineering; inspiring the integration of physical, mathematical and/or life sciences with engineering; and cultivating a vibrant, diverse community in key, emerging and core areas benefiting society. • MISSION • CBET will promote and support transformative research and education in engineering areas based on the physical, life and/or mathematical sciences; advance scientific and engineering knowledge; and develop a diverse, globally engaged workforce enhancing the economy of the United States.

10. Chemical, Bioengineering, Environmental, and Transport Systems Deputy Division Director Bob Wellek Division Director Judy Raper Senior Advisor Marshall Lih Chemical, Biochemical, and Biotechnology Systems Transport and Thermal Fluids Biomedical Engineering and Engineering Healthcare Environmental Engineering and Sustainability Process and Reaction Engineering Maria Burka Thermal Transport Processes Pat Phelan Research to Aid Persons With Disabilities Bob Jaeger Environmental Engineering Marshall Lih Interfacial Processes And Thermodynamics Bob Wellek Environmental Technology Cindy Ekstein Catalysis and Biocatalysis John Regalbuto Biomedical Engineering Semahat Demir Particulate and Multiphase Processes Marc Ingber Energy for Sustainability Trung Van Nguyen Biophotonics, Imaging & Sensing for Healthcare Leon Esterowitz Biotechnology, Biochemical & Biomass Eng Fred Heineken Fluid Dynamics Bill Schultz Environmental Sustainability Bruce Hamilton Chemical and Biological Separations Rose Wesson Combustion, Fire, and Plasma Systems Phil Westmoreland

11. Budget and Trends

12. Engineering FY 2008 Budget RequestDollars in Millions

13. 7000 35% 6000 30% 5000 25% 4000 20% 3000 15% 2000 10% 1000 5% 0 0% FY 2000 FY 2001 FY 2002 FY 2003 FY 2004 FY 2005 FY 2006 FY 2007 FY 2008 Request Projection ENG Proposals ENG Awards ENG Funding Rate NSF Funding Rate ENG and NSF Funding RatesResearch Grants ENG Proposals and Awards Funding Rate Percent

14. CBET Success Rates All actions Unsolicited proposals

15. CBET Research ThemesFY 2008

16. CBET Research Thematic Areas • Energy, Water and Sustainability • closely aligns with the ACI goals of hydrogen and solar energy, and research critical to alternative energy. • Nanoscience and Engineering • encourage utilization of research results in active nanosystems and devices • Systems and Multi-scale Approaches • overcoming barriers to quantum information processing • Integration of Life Sciences in Engineering Research • Gain advantages of “Genomic” revolution by application of engineering way of thinking Freeman, Texas Structure of Virus used for Cancer Therapy Young, Montana State University VLP (Virus-Like Particle) with attached vaccine activators produced by the cell-free process Swartz, Stanford Des Jardin,

17. Protein-protein interactions lead to the formation of a regular capsid (protein shell of a virus) Biotechnology, Biochemical and Biomass Engineering (BBB) Exploitation of Self-Organization in Virus-like Particles (VLPs) B. Dragnea Indiana University VLP Assembly Mechanism Electrostatic interaction leads to the formation of disordered protein-silver complexes Symmetric protein shells (blue) assembled around functionalized metallic cores (yellow) provide for crystallization of 3D structures

18. Biomedical Engineering (BME) CAREER: Colloidal micelles as multifunctional vaccines • Chemoattracting microspheres: • Chemoattractants released from hydrogel ‘carrier’ microspheres draw immune cells (dendritic cells) to nanoparticles for delivery of multiple drug signals • Nanoparticles containing drug are sequestered inside carrier microsphere until phagocytosed by attracted dendritic cell Darrell Irvine, MIT Darrell J. Irvine, MIT

19. ARTIFICIAL RETINA SYSTEM Mark Humayan - USC • Array of tiny electrodes attached to inner surface of retina • Currently uses an external camera • Miniature intraocular camera fits within lens sac • Allows natural movement of the eye to scan the environment Image of B'Quest crew on dock [May-Newman, San Diego State University]

20. Chemical, Biochemical and Biotechnology Systems A Synthetic Delivery Vehicle for Gene Transfer - “hitchhike” gene delivery nanoparticles onto motor protein complexes - convert chemical energy to mechanical work - carry nanoparticle cargo toward cell nuclei Suzie Pun, U. of Washington • Bloodless Biosensing • with Carbon Nanotubes- implantable capillary devices • - filled with carbon nanotubes • monitor glucose levels • without drawing blood • for diabetes and other biosensors Michael Strano, UIUC

21. FUNDING OPPORTUNITIES

22. Opportunities for Engineering at NSF • Disciplinary Research Programs • Investigator initiated awards (unsolicited) • February 1 – March 1 • August 15 – September 15 • CAREER awards • July 18 • SGER awards • Supplements • Workshops, Conferences • Engineering Education and Centers (EEC) • Engineering Research Centers (ERC) • Research Experiences for Undergraduates (REU) Sites • Research Experiences for Teachers (RET) Sites • Unsolicited Education awards • Industrial Innovation and Partnerships (IIP) • Partnership for Innovation • Industry/University Cooperative Research Centers • SBIR/STTR Programs • GOALI Awards

23. Opportunities for Engineering at NSF (cont’d) • Office of Integrative Affairs (IA) • Science and Technology Centers (STC) • Directorate of Computer Information Science and Engineering (CISE) • Division of Experimental & Integrative Affairs • Combined Research Curriculum Development & Educational Innovation Program (CRCD) • Directorate of Education and Human Resources (EHR) • Division of Undergraduate Education (DUE) • Course, Curriculum, and Laboratory Improvement (CCLI) • Division of Graduate Education (DGE) • Integrative Graduate Education and Research Training (IGERT)

24. Cyber-Enabled Discovery & Innovation (CDI) “Broaden the Nation’s capability for innovation by developing a new generation of computationally based discovery concepts and tools to deal with complex, data-rich, and interacting systems.” • ENG broadly supports research in advanced cyber-enabled engineering throughout all its divisions. • CDI investments areas include: • Complex interactions • Computational experimentation • Knowledge extraction • Virtual environments • Education in computational discovery

25. CAREER The Faculty Early Career Development (CAREER) Program: a Foundation-wide activity that offers the NSF’s most prestigious awards for new faculty members. Recognizes and supports the early career-development activities of those teacher-scholars who are most likely to become the academic leaders of the 21st century. Awardees selected on the basis of creative, career-development plans that integrate research and education. Full Proposal Deadline Date: July 17/18/19, 2008

26. Grant Opportunities for Academic Liaison with Industry (GOALI) • Improve the nation’s capacity for intellectual and economic growth by serving as a catalyst for university and industry partnerships • Effective mechanism for transfer of knowledge between academe and industry • Promotes fundamental research topics not undertaken by industry • Supports industry-university educational programs • Aims to synergize industry-university partnerships by enabling linkages: • Interdisciplinary university-industry collaborative projects (up to 3 years) • Faculty, postdoctoral fellows and students in industry (up to 1 year) • Industry engineers and scientists in academe (up to 1 year) • Supported by all NSF Directorates

27. Small Grants for Exploratory Research (SGER) High-risk research in the fields of science, engineering and education • Preliminary work on untested and novel ideas • Ventures into emerging research areas • Application of new expertise or new approaches to research topics • Quick-response research on unanticipated events • Efforts to catalyze rapid and innovative advances • submit to individual programs only after discussion with Program Manager • two-to-five pages; the maximum award amount is $200,000 for 2 year • $20-50k much more common – PD is limited in total amount he/she can award as SGERs

28. Emerging Frontiers in Research and Innovation (EFRI) • ~$25 million each year • Topics change each year • Pre-proposal required • PI plus two co-PIs from at least three disciplines • $500,000/year for 4 years • FY 2008 Topics • Resilient and Sustainable Infrastructure • Design, renew, expand, monitor, and control critical interdependent infrastructures to be both resilient and sustainable • Cognitive Optimization and Prediction through Reverse Engineering • Understanding subsymbolic intelligence can lead to development of new designs and algorithms for optimal decision making and prediction in engineered systems

29. COGNITIVE OPTIMIZATION AND PREDICTION: FROM NEURAL SYSTEMS TO NEUROTECHNOLOGY (COPN) • to understand how massively parallel circuits in brains and the associated system identification circuits address complex tasks in adaptive optimal decision-making and prediction. • to develop cognitive engineered designs or algorithms for optimal dynamic decision-making and/or prediction.

30. Important Information (NSF 07-579) www.nsf.gov/eng/efri • Proposal Information • Team Proposals Only: • 3 or more PIs • 3 or more disciplines • Award size will depend on the type of research program proposed • Up to 4 years in duration • Up to $500K/year (direct and indirect cost) • FY08 Dates • Sep 5, 2007 Information Webcast • Sep 25, 2007 Letters of Intent Due (required) • Oct 26, 2007 Preliminary Proposals Deadline • Apr 30, 2008 Full Proposals Deadline (by invitation)

31. Thank YouQuestions