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Optogenetic Neurostimulation

Optogenetic Neurostimulation. Revolutionizing Outcomes for Refractory Psychiatric Disorders. Team Bambara. More than 50 % of Parkinson’s patients cannot be effectively treated with pharmaceuticals. Treatment resistant psychiatric disorders have a large patient population.

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Optogenetic Neurostimulation

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  1. Optogenetic Neurostimulation Revolutionizing Outcomes for Refractory Psychiatric Disorders Team Bambara

  2. More than 50 % of Parkinson’s patients cannot be effectively treated with pharmaceuticals

  3. Treatment resistant psychiatric disorders have a large patient population REFRACTORY PARKINSON’S AND ESSENTIAL TREMOR: 5.5 MILLION REFRACTORY DEPRESSION: 4 MIILLION REFRACTORY EPILESPY: 1 MILLION

  4. Electrical Neurostimulation Devices: a close analog Large revenue High growth • Significant limitations • Limited efficacy • Severe side effects

  5. Optogenetic neurostimulation directly addresses these two main limitations “With its high specificity, optogenetics offers higher efficacy and fewer side effects… Neurosurgeons’ primary criteria for purchasing a device are efficacy, side effects, and reimbursement.” -Dr. Raag Airan Neurosurgeon at Johns Hopkins University

  6. Optogenetic Neurostimulation 1. Algae 2. Gene therapy Light-sensitive genes are extracted Genes are added to patient’s DNA 4. Device Mediated Brain Management Turn genes on/off with lights Control neuron activation Fiber optic cable is implanted in the brain 5. A Better Life 3. Surgery

  7. Business Model Technology Licensing: OTL Licensers: Biotech Companies IP IP $$$ IP Purchasing Decision: Neurosurgeons $$$ Capital Equipment & Disposables Device Manufacturing, Distribution, and Sales: Medtronic $$$ Care Providers: Hospitals Care $$$ Payers: Medicare/Medicaid Private Insurance End Users: Patients

  8. Major Risks Medicare/Medicaid Coverage Efficacy in humans • Gene Therapy • Safety • Regulatory approval • Market adoption Capital “We don’t yet know how to control expression for optogenetics gene therapy or if it will be safe.” -Dr. Polina Anikeeva Stanford Optogenetics Researcher

  9. Pivot: apply optogenetics to screening of novel pharmaceuticals “More than 10% of the pharmaceutical screening market is for neural drugs… Patch clamp technology for neural screening is currently too unreliable.” -Dr. Solow-Cordero Manager of Stanford High-Throughput Bioscience Center

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