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Osteoscoop - Issue N°309 – October 2013

E-selectin ligand-1 regulates bone remodeling by limiting bioactive TGF-b in the bone microenvironment. Osteoscoop - Issue N°309 – October 2013. ESL-1. Osteoblasts. TGF- b. TGF- b. proTGF. Osteoblast precursor. Low bone formation. Osteoclast precursors. Osteoclasts. ESL-1.

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Osteoscoop - Issue N°309 – October 2013

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  1. E-selectin ligand-1 regulates bone remodeling by limiting bioactive TGF-b in the bone microenvironment Osteoscoop - Issue N°309 – October 2013

  2. ESL-1 Osteoblasts TGF-b TGF-b proTGF Osteoblast precursor Low bone formation

  3. Osteoclast precursors Osteoclasts ESL-1 Osteoclast progenitor High bone resorption RANK RANKL Osteoblasts Osteoblasts TGF-b TGF-b proTGF Osteoblast precursor Low bone formation

  4. Osteoclasts ESL-1 Osteoclast precursors Osteoclast progenitor High bone resorption RANK RANKL Osteoblasts Severe osteopenia phenotype Osteoblasts TGF-b TGF-b proTGF Osteoblast precursor Low bone formation

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