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Figure S1 (related to Fig.1)

Figure S1 (related to Fig.1). A. B. Figure S2 (related to Fig.2). A. ASXL1 relative expression. Mock/Mock. ASXL1-MT/Mock. Mock/SETBP1-WT. Mock/SETBP1-D868N. ASXL1-MT/SETBP1-WT. ASXL1-MT/SETBP1-D868N. B. SETBP1 relative expression. Mock/Mock. ASXL1-MT/Mock. Mock/SETBP1-WT.

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Figure S1 (related to Fig.1)

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  1. FigureS1 (related to Fig.1) A B

  2. FigureS2 (related to Fig.2) A ASXL1 relative expression Mock/Mock ASXL1-MT/Mock Mock/SETBP1-WT Mock/SETBP1-D868N ASXL1-MT/SETBP1-WT ASXL1-MT/SETBP1-D868N B SETBP1 relative expression Mock/Mock ASXL1-MT/Mock Mock/SETBP1-WT Mock/SETBP1-D868N ASXL1-MT/SETBP1-WT ASXL1-MT/SETBP1-D868N

  3. C Relative viability D * * * ** * * * *

  4. E ①Mock/Mock ②ASXL1-MT/Mock ③Mock/SETBP1-WT ④Mock/SETBP1-D868N ⑤ASXL1-MT/SETBP1-WT ⑥ASXL1-MT/SETBP1-D868N F Mature cells (%) * * ** ** *** Immature cells (%) *** ** * * * * ** ** CD11b MFI ①Mock/Mock ②ASXL1-MT/Mock ③Mock/SETBP1-WT ④Mock/SETBP1-D868N ⑤ASXL1-MT/SETBP1-WT ⑥ASXL1-MT/SETBP1-D868N

  5. FigureS3 (related to Fig.4) A ASXL1 relative expression ASXL1-MT/SETBP1-D868N Mock B SETBP1 relative expression ASXL1-MT/SETBP1-D868N Mock

  6. C *** *** Relative growth rate *** * D

  7. E c-kit Gr1 ScaI CD11b CD34 B220 NGFR =ASXL1-MT FcεRIα SETBP1-D868N (GFP)

  8. FigureS4 (related to Fig.5) A In vitro In vivo - + - + FTY720 P-PP2A P=0.0906 PP2A tublin B

  9. FigureS4 (related to Fig.5) C * * D * * * *

  10. FigureS5 (related to Fig.6) A NES=1.70 P=0.000 AML MDS B NES=1.78 P=0.000 AML MDS C NES=-1.34 P=0.017 AML MDS

  11. D NES=-1.57 P=0.016 AML MDS E NES=-1.13 P=0.071 AML MDS F NES=1.41 P=0.000 AML MDS

  12. G NES=1.42 P=0.021 MDS Control

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