Pain Management in Individuals with Developmental Disabilities

1. Pain Management in Individuals with Developmental Disabilities Irene Zamora, MSN, RN, CNS Certified Pain Management Nurse Hospital of the University of Pennsylvania Philadelphia, PA

2. Objectives • Describe the physiologic response to pain • Discuss the best approach for assessment of pain • Identify three strategies and reasons for the adequate treatment of pain

3. CLARIFYING TERMINOLOGY • Opioids vs narcotics • Tolerance – After receiving med regularly for ~7 days • Treat by increasing the dose • Physical/chemical dependence – after receiving med regularly for ~7 days, pt. will experience withdrawals if dc’d abruptly • Treat by gradually reducing med • Addiction – An overwhelming and compulsive need to obtain and use drugs for their psychic effects despite consequences • Pseudoaddiction—under treated pain

4. Endocrine Metabolic Cardiovascular Respiratory Genitourinary Gastrointestinal Musculoskeletal Cognitive Immune Developmental Future pain Quality of Life EFFECTS OF UNTREATED PAIN– STRESS RESPONSE

5. FUTURE PAIN and QUALITY OF LIFE • Untreated pain can result in • chronic pain • Other chronic pain syndromes • Quality of Life • Decreased physical activity • Thoughts of suicide • What is suffering? • Anguish, agony, misery, torment, distress • Inability to experience joy

6. Types of Pain • Nociceptive vs Neuropathic • Physiologic vs pathophysiologic • Acute vs chronic • Malignant vs nonmalignant • Pain syndromes

7. Nociceptive Pain (Acute Pain/Physiologic Pain) Pain resulting from activation of primary afferent nociceptors by mechanical, thermal or chemical stimuli

8. Pain Mechanisms: The “Pain Process” • The neural mechanisms by which pain is perceived involve a process that involves four major steps: 1. Transduction 4 2. Transmission 3. Modulation major steps 4. Perception

9. 5HT BK H PGE Trauma Transduction:Nociceptive Chemical Stimuli Afferent Fiber EfferentSympathetic Fiber Tissue

10. Neuropathic painPathophysiologic Pain • Pain resulting from damage to peripheral nervous or central nervous system tissue or from altered processing of pain in the central nervous system

11. Neuropathic—Pathophysiologic Pain • Results in cellular changes that occur in peripheral and central nervous systems • Results in sensitization to the transmission of pain signals • Neuroplasticity—ability of neurons to change their structure and function • Peripheral and central sensitization—response to stimuli is increased

12. Result of Central and Peripheral Changes • Hyperalgesia • Primary hyperalgesia • Secondary hyperalgesia • Allodynia • 'wind-up' of C fibers (a phenomenon of progressively increased neural response to repeated noxious stimuli)

13. Examples of Neuropathic Pain • Post herpetic neuralgia (PHN) • Neuropathic low back pain • Post laminectomy syndrome • Diabetic neuropathy • Trigeminal neuralgia • Peripheral neuropathies due to chemotherapy • CRPS

14. Multiple Dimensions of Pain The ABCs of Pain Affective Dimension Behavioral Dimension Cognitive Dimension Physiological-Sensory Dimension

15. Definition of Pain “Unpleasant sensory and emotional experience arising from actual or potential tissue damage or described in terms of such damage (IASP)

16. Pain Assessment • Self-reporting is considered the gold standard and should be used whenever possible • VAS • NRS • VDS • Faces • Functional based outcomes

17. Wong-Baker Faces Pain Scale Explain to the person that each face is for a person who has no pain (hurt) or some, or a lot of pain. Face 0 doesn’t hurt at all. Face 2 hurts just a little bit. Face 4 hurts a little more. Face 6 hurts even more. Face 8 hurts a whole lot. Face 10 hurts as much as you can imagine, although you don’t have to be crying to have this worst pain. Ask the person to choose the face that best describes how much pain he has.

18. Visual Analog Scale (VAS)When using the VAS ask the patient to pick the number that best describes their pain with 0 representing no pain, 6 and above representing severe pain and 10 representing unbearable pain.

19. Pain Indicator for Communicatively Impaired Children (PICIC) Most common cues identified by 67 parents: • Screwed up or distressed looking face • Crying with or without tears • Screaming, yelling, groaning, moaning • Stiff or tense body • Difficult to comfort or console • Flinches or moves away if touched Ref: Stallard P, et al: Pain 98(1-2):145-149, 2002.

20. Assessment in the Cognitively Impaired • Direct observation or history from caregivers • Assessment by proxy—nursing assistants or family members or regular caregivers • Observe during movement (walking, morning care, transfers • Unusual behavior should trigger assessment of pain

21. Common Pain Behaviors in Cognitively Impaired Elderly Persons • Facial expressions • Verbalizations, vocalizations • Body movements • Changes in interpersonal interactions • Changes in activity patterns or routines • Mental status changes

22. Less-obvious Pain Indicators • May be attributed to psychosis or dementia • Aggressive behavior • Fidgeting • Noisy breathing • Rapid blinking • Rigid, tense body posture • Untreated pain can increase confusion • Patients on opioids at risk for dose being cut

23. CNPI—at rest and with movement Vocal complaints: Non-verbal (Expression of pain, not in words,moans, groans, grunts, cries, gasps, sighs)  Facial Grimaces/Winces (Furrowed brow, narrowed eyes, tightened lip jaw drop, clenched teeth, distorted expressions). Bracing (Clutching or holding onto side rails, bed, tray table, or affected area during movement)  Restlessness (Constant or intermittent shifting of position, rocking, intermittent or constant hand motions, inability to keep still)  Rubbing: (Massaging affected area) (In addition, record Verbal complaints).  Vocal complaints: Verbal (Words expressing discomfort or pain, "ouch“ "that hurts"; cursing during movement,or exclamations of protest ‘stop’,’that’s enough’.) Feldt, K. S. (1996). Treatment of pain in cognitively impaired versus cognitively intact post hip fractured elders. (Doctoral dissertation, University of Minnesota, 1996). Dissertation Abstracts International, 57-09B, 5574. Feldt, K.S. (2000). Checklist of Nonverbal Pain Indicators. Pain Management Nursing, 1 (1), 13-21.

24. Assume Pain is Present • Assume Pain is Present • Is there a painful stimulus • Surgical incision • Fracture • Painful procedure • Any tissue damage • If so, treat • Observe

25. Medication Management--Analgesics

26. Pharmacologic treatment • Analgesics • Combine non-opioids with opioids • Characteristics of opioids • No ceiling effect • No end organ damage • Cause tolerance and physical dependence • Metabolized by the liver • Excreted by the kidney • Cause constipation • Reversible with an antagonist • Tolerance to side effects EXCEPT constipation

27. Morphine Fentanyl hydromorphone oxycodone hydrocodone Codeine *Methadone *meperedine *propoxyphene *tramadol OpioidsMu-agonists Bind to mu opiate receptors blocking transmission of pain

28. Non-Pharmacologic Interventions • Increase activity • Individualize interventions • music • artwork • humor • Address constipating effects of opioids

29. Goal Setting • Once assessment complete, discuss pain level and related goals with patient & family • Should be based on functionality • Decrease suffering • Be realistic • Be patient • Patient education—why pain management • Minimize risk of complications • Myths about addiction

30. Documentation • Analgesia • Adverse effects • ADLs • Aberrhant behavior

31. In Summary • Treat pain initially aggressively— • ***Titrate to Effect • Adequate analgesia results in: • Early participation in activity • Prevention of complications • Possible prevention of chronic pain • Improved quality of life • Individualize assessment • Always combine modalities—pharmacologic with non-pharmacologic