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Eukaryotic Loci

Eukaryotic Loci. One Locus, Multiple Proteins,. Environmentally * Responsive,. D iversity of Gene “Products,”. Oct. 4, 2005. Tight Control on Expression of Diversity. *Biotic & Abiotic Influences. Central Dogma plus cell biology (1980). Simplified Reality. 1970. 1990. 2000.

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Eukaryotic Loci

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  1. Eukaryotic Loci One Locus, Multiple Proteins, Environmentally* Responsive, Diversity of Gene “Products,” Oct. 4, 2005 Tight Control on Expression of Diversity *Biotic & Abiotic Influences

  2. Central Dogma plus cell biology (1980) Simplified Reality

  3. 1970 1990 2000 2002 2001 1980 2003 1990 Central Dogma of Genetics – 1960+

  4. What is Assumed ?What are Necessary Conditions?

  5. Small RNAs thatsilence genes, and alter the transcription initiation site Emerging Reality - 2003 2003 Control of IgE prod’n:Nature Imm. 4(1):7 Asthma incidence: Nature Imm. 3(8):715

  6.  2000genes  3300genes(humoral) >5000 genes More Realistic - 2000

  7. Reality(1985) 10% of the cells from parents 90% of the cells from bacteria Genes & Cells From Parents’ Gametes 1900 We are a product of our Genes and our Env’t.

  8. Transcription & Translation Regulation • Prokaryotes vs. Eukaryotes • Complexity of “switches” • Effects of nuclear membrane on regulation mechanisms • Effects of gene “architecture” on regulation • Effects of gene “architecture” on gene product diversity Note Chapters 12, 13, 14

  9. Repressor binding Multiple loci activity Diverse binding affinity Induced or repressed Binding “helpers” Mutiple targets at a locus DNA &/or RNA folding Regulator sRNAs (ribozyme) Micro RNAs Antisense gene RNA sRNA nuclear (reg. translation) RNAi silences genes dsRNAs Operons and Eukaryotes have complex regulation Then in both,(with some differences) First in prokaryotes

  10. Review Previous Questions • Conditions for living organisms • Conditions for regulation of processes • Intrinsic conditions • Extrinsic conditions • Delayed response, rapid response • Off/On vs. Less/More • Explicit conditions • Implicit conditions • Unknowns Chapters 10, 11, 12

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