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Environmental Carcinogens

Environmental Carcinogens. Jeremy Reinert. Carcinogens. Natural or synthetic substances that can cause cancer Viruses and Microorganisms Radiation Chemical Agents Physical Agents. Viruses and Microorganisms. Oncogenic viruses involved in an estimated 16% of Neoplasia worldwide.

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Environmental Carcinogens

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  1. Environmental Carcinogens Jeremy Reinert

  2. Carcinogens • Natural or synthetic substances that can cause cancer • Viruses and Microorganisms • Radiation • Chemical Agents • Physical Agents

  3. Viruses and Microorganisms • Oncogenic viruses involved in an estimated 16% of Neoplasia worldwide. • DNA and RNA viruses associated with human cancers. • HPV • Hepatitis B • Hepatitis C • HTLV-1

  4. Vir. and Mic. Cont… • Strong biological and epidemiological relations to infectious viral origins. • More frequent in high-income countries.

  5. Radiation • Speculated to represent 10%of cases • Random late effect of ionizing or non-ionizing radiation • Leukemia, lymphoma, thyroid cancer, breast cancer • Nuclear radiation and UV radiation

  6. Chemical Agents • Industrial Revolution • ~100,000 different chemicals since last world war • Indoor air pollution • PAH • ETS • VOC

  7. Physical Agents • Epigenetic events • Hypermethylation • Hypomethylation • Can cause genetic predisposition for cancer

  8. Regulation • Limit exposure • Awareness education • Source reduction

  9. References • The multitude and diversity of environmental carcinogens.www.elsevier.com/locate/envres. Environmental Research 105, (2007) 414-429. • Environmental and chemical carcinogenesis.www.elsevier.com/locate/semcancer. Seminars in Cancer Biology 14, (2004) 473-486 • Issues in the Regulation of Environmental Carcinogens. Journal of Public Health Policy. www.jstor.org/stable/3342005. • Epigenetics and the Environment. New York Academy of Sciences 983, (2003) 151-160

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