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Determine protein structure from amino acid sequence. Ray Luo UC Berkeley EECS

?. Determine protein structure from amino acid sequence. Ray Luo UC Berkeley EECS. Polypeptide: amino acid sequence. Folded protein: 3D structure. Information flows from DNA to RNA to polypeptide string to folded protein.

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Determine protein structure from amino acid sequence. Ray Luo UC Berkeley EECS

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  1. ? Determine protein structure from amino acid sequence.Ray LuoUC Berkeley EECS UC Berkeley :: EECS :: rluo@uclink

  2. Polypeptide: amino acid sequence Folded protein: 3D structure Information flows from DNA to RNA to polypeptide string to folded protein. UC Berkeley :: EECS :: rluo@uclink

  3. Amino acid sequence encodes the 3D structure and function of a protein. UC Berkeley :: EECS :: rluo@uclink

  4. Protein in database New protein : Protein in database Alignment { : New protein Comparative methods align sequence against known proteins in a database. UC Berkeley :: EECS :: rluo@uclink

  5. Transition state - Free energy Unfolded protein Folded protein Reaction coordinate De novo methods search for a stable structure by simulating protein folding. UC Berkeley :: EECS :: rluo@uclink

  6. De novo ? Comparative Most proteins have complicated 3D structures requiring efficient algorithms. UC Berkeley :: EECS :: rluo@uclink

  7. Cooperative Approach: Protein folding Clustering Sampling Sequence alignment Utilize de novo simulation to support comparative alignment and vice versa. UC Berkeley :: EECS :: rluo@uclink

  8. Protein folding Sequence alignment Determine protein structure from amino acid sequence using comparative alignment and protein folding simulation. UC Berkeley :: EECS :: rluo@uclink

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