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The Two Bioinorganic Projects of Research Methodology Fall 2012

The Two Bioinorganic Projects of Research Methodology Fall 2012. Tetraphenyl porphyrin. Ligand Synthesis. Pteridinyl phenanthroline. Complex Synthesis. Biochemical Studies. Types of Pteridinyl Phenanthroline Ligands (and other). L-UN. L-amino. L- keto. DPPZ. L- allox.

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The Two Bioinorganic Projects of Research Methodology Fall 2012

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  1. The Two Bioinorganic Projects of Research Methodology Fall 2012 Tetraphenylporphyrin Ligand Synthesis Pteridinyl phenanthroline Complex Synthesis Biochemical Studies

  2. Types of PteridinylPhenanthroline Ligands (and other) L-UN L-amino L-keto DPPZ L-allox

  3. Ligand Synthesis (by Alexandra) Pteridinylphenanthroline synthesis MeOH 20 h or so in NaOH pH ~11

  4. General Description of Ligand Synthesis

  5. Group and Ligand Assignments for Synthesis and Characterization Group # Students ligand complex Group 1 — Linda Cho, Katie GuyeDPPZ [Ru(bpy)2(DPPZ)](PF6)2 Group 2 — Rachael Kahlin,JuliaHeerL-allox [Ru(bpy)2(L-allox)](PF6)2 Group 3 — Julie Han,BingqingLi L-amino [Ru(bpy)2(L-amino)](PF6)2 Group 4 — Alicia Makepeace,MishaSims L-keto [Ru(bpy)2(L-keto)](PF6) Group 5 — Terry Huh,MariaNam L-keto [Ru(bpy)2(L-keto)](PF6)2 Group 6 — Anna Kalinsky,JanielleVidal L-keto (to make L-aap) [Ru(bpy)2(L-aap)](PF6)2 Group 7— Chloe Baumann,SaraKim L-UN (to make L-alap) [Ru(bpy)2(L-alap)](PF6)2 ‘Group’ 8 — Alexandra Kirsch L-tallox (thioalloxazine) [Ru(bpy)2(L-tallox)](PF6)2 L-UN L-amino L-keto DPPZ L-allox w/ Ru w/ Ru L-aap L-alap

  6. Group and Ligand Assignments for Synthesis and Characterization Group # Students ligand complex Group 1 — Linda Cho, Katie GuyeDPPZ [Ru(bpy)2(DPPZ)](PF6)2 Group 2 — Rachael Kahlin,JuliaHeerL-allox [Ru(bpy)2(L-allox)](PF6)2 Group 3 — Julie Han,BingqingLi L-amino [Ru(bpy)2(L-amino)](PF6)2 Group 4 — Alicia Makepeace,MishaSims L-keto [Ru(bpy)2(L-keto)](PF6) Group 5 — Terry Huh,MariaNam L-keto [Ru(bpy)2(L-keto)](PF6)2 Group 6 — Anna Kalinsky,JanielleVidal L-keto (to make L-aap) [Ru(bpy)2(L-aap)](PF6)2 Group 7— Chloe Baumann,SaraKim L-UN (to make L-alap) [Ru(bpy)2(L-alap)](PF6)2 ‘Group’ 8 — Alexandra Kirsch L-tallox (thioalloxazine) [Ru(bpy)2(L-tallox)](PF6)2 L-UN L-amino L-keto DPPZ L-allox Phenylene diamine 5,6 –diamino 2,4 dihydroxy pyrimidine 5,6 –diamino 4-hydroxy pyrimidine 4,5,6 –triamino pyrimidine 5,6 –diamino pyrimidine

  7. True or false? Blood is red because of the iron in hemoglobin. “Red blood cells” A close-up of red blood cells within a capillary. Over 99 percent of the blood vessels in the body are capillaries, even though they only hold 5 percent of the body’s blood.

  8. False por·phy·rin Function: noun Etymology: from Greek porphyrapurple -any of various compounds with a macrocyclic structure that consists essentially of four pyrrole rings joined by four =CH- groups; especially : one (as chlorophyll or hemoglobin) containing a central metal atom and usually exhibiting biological activity

  9. Nature’s synthesis of Porphyrin the pyrrole ring is formed Glycine + Succinyl CoA Protoporphyrin IX

  10. The Adler synthesis of simple, symmetrically substituted porphyrins: Meso position R = phenyl (TPP) toluyl (TTP) p-chlorophenyl (TClPP)

  11. Ligand Synthesis: Condensations are a Theme Schiff-Base Ligands

  12. (Thanks, Eesha….)

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