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Lecture 12a.

Lecture 12a. Nervous System Overview. Topics. Divisions of the NS: CNS and PNS Structure and types of neurons Synapses Structure and function of glia in the CNS and PNS. The Nervous System. Includes all neural tissue in the body. General Overview. Neural Tissue.

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Lecture 12a.

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  1. Lecture 12a. Nervous System Overview

  2. Topics • Divisions of the NS: CNS and PNS • Structure and types of neurons • Synapses • Structure and function of glia in the CNS and PNS

  3. The Nervous System • Includes all neural tissue in the body

  4. General Overview

  5. Neural Tissue • Contains 2 kinds of cells: • neurons: • cells that send and receive signals • neuroglia (glial cells): • cells that support and protect neurons

  6. Organs of the Nervous System • Brain and spinal cord • Sensory receptors of sense organs (eyes, ears, etc.) • Nerves connect nervous system with other systems

  7. Anatomical Divisions of the Nervous System • Central nervous system (CNS) • Peripheral nervous system (PNS)

  8. Nervous System CNS PNS Somatic NS Autonomic NS Sympathetic Parasympathetic

  9. The Central Nervous System (CNS) • Consists of the spinal cord and brain • Contain neural tissue, connective tissues, and blood vessels

  10. Functions of the CNS • Are to process and coordinate: • sensory data: • from inside and outside body • motor commands: • control activities of peripheral organs (e.g., skeletal muscles) • higher functions of brain: • intelligence, memory, learning, emotion

  11. The Peripheral Nervous System (PNS) • Includes all neural tissue outside the CNS (nerves that control muscles and glands)

  12. Functions of the PNS • Deliver sensory information to the CNS • Carry motor commands to peripheral tissues and systems

  13. Nerves • Also called peripheral nerves: • bundles of axons with connective tissues and blood vessels • carry sensory information and motor commands in PNS: • cranial nerves—connect to brain • spinal nerves—attach to spinal cord

  14. Functional Divisions of the PNS • Afferent division: • carries sensory information • from PNS sensory receptors to CNS • Efferent division: • carries motor commands • from CNS to PNS muscles and glands SAME: Sensory is Afferent, Motor is Efferent

  15. PNS divisions • Somatic nervous system (SNS) • Autonomic nervous system (ANS)

  16. The Somatic Nervous System (SNS) • Controls skeletal muscle contractions: • voluntary muscle contractions • involuntary muscle contractions (reflexes)

  17. The Autonomic Nervous System (ANS) • Controls subconscious actions: • contractions of smooth muscle and cardiac muscle • glandular secretions

  18. Divisions of the ANS • Sympathetic division: • has a stimulating effect • Parasympathetic division: • has a relaxing effect

  19. Nervous System CNS PNS Somatic NS Autonomic NS Sympathetic Parasympathetic

  20. Neurons • The basic functional units of the nervous system

  21. The Structure of Neurons Figure 12–1

  22. Major Organelles of the Cell Body • Large nucleus and nucleolus • Cytoplasm (perikaryon) • Mitochondria (produce energy) • RER and ribosomes (produce neurotransmitters) • Cytoskeleton • Nissl Bodies: RER and ribosomes

  23. Dendrites • Highly branched • Dendritic spines: • many fine processes • receive information from other neurons • 80–90% of neuron surface area

  24. The Axon • Are long • Carries electrical signal (action potential) to target • Axon structure is critical to function

  25. Structures of the Axon • Axon hillock: • thick section of cell body • attaches to initial segment • Initial segment: • attaches to axon hillock • Collaterals: • branches of a single axon • Synaptic terminals with knobs: • tips of axon (knobs at ends)

  26. Movie Neurophysiology: Neuron Structure

  27. The Synapse Figure 12–2

  28. Synapse • Synapse: Area where a neuron communicates with another cell • Presynaptic cell: • neuron that sends message • Postsynaptic cell: • cell that receives message • Synaptic cleft The small gap that separates the presynaptic membrane and the postsynaptic membrane • Area of terminal containing synaptic vesicles filled with neurotransmitters

  29. Neurotransmitters • Chemical messengers (like ACh) • Released at presynaptic membrane • Affect receptors of postsynaptic membrane • Broken down by enzymes and/or taken up into presynaptic cell • Are reassembled at synaptic knob

  30. Major Structural Classifications of Neurons • Unipolar neurons: • found in sensory neurons of PNS • Multipolar neurons: • common in the CNS • include all skeletal muscle motor neurons • cell body (soma) • short, branched dendrites • long, single axon

  31. Unipolar Neurons • Have very long axons • Dendrites fused to axon • Cell body to 1 side Figure 12–3 (3 of 4)

  32. Multipolar Neurons • Often have long axons • Multiple dendrites, 1 axon Figure 12–3 (4 of 4)

  33. 3 Functional Classifications of Neurons • Sensory neurons: • afferent neurons of PNS • Motor neurons: • efferent neurons of PNS • Interneurons: • association neurons

  34. Sensory (Afferent) Neurons • Monitor internal environment (visceral sensory neurons) • Monitor effects of external environment (somatic sensory neurons)

  35. Motor (Efferent)Neurons • Signals from CNS motor neurons to visceral effectors pass synapses at autonomic ganglia dividing axons into: • preganglionic fibers • postganglionic fibers

  36. Interneurons • Most are located in brain, spinal cord, and autonomic ganglia: • between sensory and motor neurons • Are responsible for: • distribution of sensory information • coordination of motor activity • Are involved in higher functions: • memory, planning, learning

  37. Neuroglia are supporting cells

  38. Neuroglia • Half the volume of the nervous system • Many types of neuroglia in CNS and PNS

  39. Neuroglia of the Central Nervous System Figure 12–4

  40. 4 Types of Neuroglia in the CNS • Ependymal cells • Astrocytes • Microglia • Oligodendrocytes

  41. 1. Ependymal Cells • Form epithelium called ependyma • Line central canal of spinal cord and ventricles of brain: • secrete cerebrospinal fluid (CSF) • have cilia or microvilli that circulate CSF • monitor CSF • contain stem cells for repair

  42. 2. Astrocytes • Maintain blood–brain barrier (isolates CNS) • Create 3-dimensional framework for CNS • Repair damaged neural tissue • Guide neuron development • Control interstitial environment

  43. 3.Microglia • Migrate through neural tissue • Clean up cellular debris, waste products, and pathogens • Not of neural origin; related to macrophages (like osteoclasts)

  44. 4. Oligodendrocytes • Processes contact other neuron cell bodies • Wrap around axons to form myelin sheaths

  45. Myelination • Increases speed of action potentials • Myelin insulates myelinated axons • Makes nerves appear white

  46. Nodes and Internodes • Internodes: • myelinated segments of axon • Nodes: • also called nodes of Ranvier • gaps between internodes • where axons may branch

  47. White Matter and Gray Matter • White matter: • regions of CNS with many myelinated nerves • Gray matter: • unmyelinated areas of CNS

  48. 2 Neuroglia of the Peripheral Nervous System • Satellite cells (amphicytes) • Schwann cells (neurilemmacytes)

  49. 1. Satellite Cells • Surround ganglia • Regulate environment around neuron

  50. Ganglia vs Nuclei • Masses of neuron cell bodies • Called ganglia in the PNS and are surrounded by satellite cells • Called nuclei in the CNS

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