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Rubella in Pregnancy

Rubella in Pregnancy. Max Brinsmead PhD FRANZCOG October 2008. Rubella Infection. Caused by the pleomorphic RNA virus of the genus Rubivirus Infects only human subjects In adults and children causes: Mild fever & malaise Generalised fine erythematous rash – rarely purpuric

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Rubella in Pregnancy

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  1. Rubella in Pregnancy Max Brinsmead PhD FRANZCOG October 2008

  2. Rubella Infection • Caused by the pleomorphic RNA virus of the genus Rubivirus • Infects only human subjects • In adults and children causes: • Mild fever & malaise • Generalised fine erythematous rash – rarely purpuric • Cervical lymphadenopathy • Arthralgia

  3. Rubella in a Pregnant Woman • Before 12 weeks pregnancy • Miscarriage • Cardiac anomalies • Nerve deafness • Cataracts or retinopathy • Mental retardation • Fetus somewhat safer in the 2nd trimester but… • In the second half of pregnancy • Hepatosplenomegaly • Failure to thrive, osteitis • Diabetes, hypothyroidism and GH deficiency • Progressive panencephalitis = The Congenital Rubella Syndrome

  4. Prevention of Congenital Rubella • Immunise all children at 12 -15m (MMR) • Test all women who are pregnant (or plan to conceive) for immunity • Avoid infection if pregnant • Spread by nasopharyngeal droplets +/- 7 days from the time of rash • Retest any pregnant woman who is exposed to the virus • Terminate pregnancy for proven infection • Immunise women postpartum if low titre or non immune • Immunisation of a pregnant woman with the live virus is not recommended but is also not associated with teratogenesis

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