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Gram Negative Gram Positive

Gram Negative Gram Positive. Two Drug Bugs. Aerobes. S erratia P seudomonas A cinetobactor C itrobactor E nterobactor. Salmonella Shigella. H. Flu Klebsiella E. Coli. MRSA MRSE. VRE. Staph. Strep.

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Gram Negative Gram Positive

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  1. Gram Negative Gram Positive Two Drug Bugs Aerobes Serratia Pseudomonas Acinetobactor Citrobactor Enterobactor Salmonella Shigella H. Flu Klebsiella E. Coli MRSA MRSE VRE Staph Strep Oral Anaerobes Bacteroides Bacteroides Fragilis – Gut Melanogenicus – Respiratory Clostridium Difficile Anaerobes

  2. Gram Negative Gram Positive Penicillin (Pen G, Pen VK) Aerobes Serratia Pseudomonas Acinetobactor Citrobactor Enterobactor Salmonella Shigella H. Flu Klebsiella E. Coli MRSA MRSE VRE Strep Staph Oral Anaerobes Bacteroides Clostridium Difficile Anaerobes

  3. Gram Negative Gram Positive Synthetic Penicillins Augmentin / Unasyn (w/ beta lactamase inhibitor) Ampicillin / Amoxicillin Aerobes Serratia Pseudomonas Acinetobactor Citrobactor Enterobactor Salmonella Shigella H. Flu Klebsiella E. Coli Beta Lactamase Beta Lactamase MRSA MRSE VRE Strep Staph Oral Anaerobes Bacteroides Clostridium Difficile Anaerobes

  4. Gram Negative Gram Positive Synthetic Penicillins Nafcillin / Methicillin//Dicloxacillin Ampicillin / Amoxicillin Aerobes Serratia Pseudomonas Acinetobactor Citrobactor Enterobactor Salmonella Shigella H. Flu Klebsiella E. Coli Beta Lactamase MRSA MRSE VRE Strep Staph Oral Anaerobes Bacteroides Clostridium Difficile Anaerobes

  5. Gram Negative Gram Positive Anti-Pseudomonal Penicillins Zosyn / Timentin (w/ beta lactamase inhibitor) Piperacillin Penicillin (Pen G, Pen VK) Aerobes Serratia Pseudomonas Acinetobactor Citrobactor Enterobactor Salmonella Shigella Proteus Mirabilis H. Flu Klebsiella E. Coli Beta Lactamase MRSA MRSE VRE Strep Staph Oral Anaerobes Bacteroides Clostridium Difficile Anaerobes Spotty lines mean spotty coverage, look up individual coverages for SPACE bugs other than Pseudomonas

  6. Gram Negative Gram Positive First Generation Cephalosporins Cephalexin, cefazolin, cefadroxil Aerobes Serratia Pseudomonas Acinetobactor Citrobactor Enterobactor Salmonella Shigella H. Flu Klebsiella E. Coli MRSA MRSE VRE Strep Staph Oral Anaerobes Oral Anaerobes Bacteroides Clostridium Difficile Anaerobes

  7. Gram Negative Gram Positive Second Generation Cephalosporins Cephalexin, cefazolin, cefadroxil Cefuroxime, Cefotetan, cefoxitin Aerobes Serratia Pseudomonas Acinetobactor Citrobactor Enterobactor Salmonella Shigella H. Flu Klebsiella E. Coli MRSA MRSE VRE Strep Staph Cefoxitin and Cefotetan only Oral Anaerobes Oral Anaerobes Bacteroides Clostridium Difficile Anaerobes

  8. Gram Negative Gram Positive Third Generation Cephalosporins Cephalexin, cefazolin, cefadroxil Ceftriaxone, Cefotaxime, Cefdinir Aerobes Serratia Pseudomonas Acinetobactor Citrobactor Enterobactor Salmonella Shigella H. Flu Klebsiella E. Coli MRSA MRSE VRE Strep Staph Ceftazidime Oral Anaerobes Oral Anaerobes Bacteroides Clostridium Difficile Anaerobes

  9. Gram Negative Gram Positive Fourth Generation Cephalosporins Cephalexin, cefazolin, cefadroxil Cefipime (Maxipime) Aerobes Serratia Pseudomonas Acinetobactor Citrobactor Enterobactor Salmonella Shigella H. Flu Klebsiella E. Coli MRSA MRSE VRE Strep Staph Oral Anaerobes Oral Anaerobes Bacteroides Clostridium Difficile Anaerobes

  10. Gram Negative Gram Positive Carbapenems Meropenem, Imipenem, Ertapenem Aerobes Serratia Pseudomonas Acinetobactor Citrobactor Enterobactor Salmonella Shigella H. Flu Klebsiella E. Coli MRSA MRSE VRE Strep Staph Ertapenem= No Pseudomonas Oral Anaerobes Oral Anaerobes Bacteroides Clostridium Difficile Anaerobes

  11. Gram Negative Gram Positive Monobactams Aztreonam Aerobes Serratia Pseudomonas Acinetobactor Citrobactor Enterobactor Salmonella Shigella H. Flu Klebsiella E. Coli MRSA MRSE VRE Strep Staph Oral Anaerobes Oral Anaerobes Bacteroides Clostridium Difficile Anaerobes

  12. Gram Negative Gram Positive Aminoglycosides Gentamicin, Tobramycin, Amikacin Aerobes Serratia Pseudomonas Acinetobactor Citrobactor Enterobactor Salmonella Shigella H. Flu Klebsiella E. Coli MRSA MRSE VRE Strep Staph Oral Anaerobes Oral Anaerobes Bacteroides Clostridium Difficile Anaerobes

  13. Gram Negative Gram Positive Carbapenems Meropenem, Imipenem, Ertapenem Aerobes Serratia Pseudomonas Acinetobactor Citrobactor Enterobactor Salmonella Shigella H. Flu Klebsiella E. Coli MRSA MRSE VRE Strep Staph Ertapenem= No Pseudomonas Oral Anaerobes Oral Anaerobes Bacteroides Clostridium Difficile Anaerobes

  14. Gram Negative Gram Positive Simple Fluroquinolones Cephalexin, cefazolin, cefadroxil Ciprofloxacin, Ofloxacin, Norfloxacin Aerobes Serratia Pseudomonas Acinetobactor Citrobactor Enterobactor Salmonella Shigella H. Flu Klebsiella E. Coli MRSA MRSE VRE Strep Staph Ciproflxoci9n best FQ for Pseudomonas Oral Anaerobes Oral Anaerobes Bacteroides Clostridium Difficile Anaerobes Fluroquinolones also cover atypicals like Chlamydia, Legionella and Mycoplasma

  15. Gram Negative Gram Positive Simple Fluroquinolones Cephalexin, cefazolin, cefadroxil Ciprofloxacin, Ofloxacin, Norfloxacin Aerobes Serratia Pseudomonas Acinetobactor Citrobactor Enterobactor Salmonella Shigella H. Flu Klebsiella E. Coli MRSA MRSE VRE Strep Staph Ciproflxoci9n best FQ for Pseudomonas Oral Anaerobes Oral Anaerobes Bacteroides Clostridium Difficile Anaerobes Fluroquinolones also cover atypicals like Chlamydia, Legionella and Mycoplasma

  16. Gram Negative Gram Positive “Respiratory” Fluroquinolones Cephalexin, cefazolin, cefadroxil Levofloxacin Aerobes Serratia Pseudomonas Acinetobactor Citrobactor Enterobactor Salmonella Shigella H. Flu Klebsiella E. Coli MRSA MRSE VRE Strep Staph ** Oral Anaerobes Oral Anaerobes Bacteroides Clostridium Difficile Anaerobes Fluroquinolones also cover atypicals like Chlamydia, Legionella and Mycoplasma ** Resistance develops quickly

  17. Gram Negative Gram Positive “Broad Spectrum” Fluroquinolones Cephalexin, cefazolin, cefadroxil Moxifloxacin Aerobes Serratia Pseudomonas Acinetobactor Citrobactor Enterobactor Salmonella Shigella H. Flu Klebsiella E. Coli MRSA MRSE VRE Strep Staph Oral Anaerobes Oral Anaerobes Bacteroides Clostridium Difficile Anaerobes Fluroquinolones also cover atypicals like Chlamydia, Legionella and Mycoplasma ** Resistance develops quickly

  18. Gram Negative Gram Positive Macrolides Cephalexin, cefazolin, cefadroxil Eythromycin, Clarithromycin, Azithromycin Aerobes Serratia Pseudomonas Acinetobactor Citrobactor Enterobactor Salmonella Shigella H. Flu Klebsiella E. Coli MRSA MRSE VRE Strep Staph Oral Anaerobes Oral Anaerobes Bacteroides Clostridium Difficile Macrolides also cover atypicals like Chlamydia, Legionella and Mycoplasma, Toxoplasmosis

  19. Gram Negative Gram Positive Ketolides Cephalexin, cefazolin, cefadroxil Telithromyicin Aerobes Serratia Pseudomonas Acinetobactor Citrobactor Enterobactor Salmonella Shigella H. Flu Klebsiella E. Coli MRSA MRSE VRE Strep Staph Oral Anaerobes Oral Anaerobes Bacteroides Clostridium Difficile Macrolides also cover atypicals like Chlamydia, Legionella and Mycoplasma, Toxoplasmosis

  20. Gram Negative Gram Positive Tetracyclines Cephalexin, cefazolin, cefadroxil Tetracycline, Doxycycline, Minocycline Aerobes Serratia Pseudomonas Acinetobactor Citrobactor Enterobactor Salmonella Shigella H. Flu Klebsiella E. Coli MRSA MRSE CA-MRSA VRE Strep Staph Lots of Resistance!! Moderate Activity against anerobes Oral Anaerobes Oral Anaerobes Bacteroides Clostridium Difficile Tetracyclines also cover atypicals like Chlamydia, Legionella and Mycoplasma,

  21. Gram Negative Gram Positive Tigecycline Aerobes Serratia Pseudomonas Acinetobactor Citrobactor Enterobactor Salmonella Shigella H. Flu Klebsiella E. Coli MRSA MRSE VRE Strep Staph Oral Anaerobes Oral Anaerobes Bacteroides Clostridium Difficile Tigecylcine also covers atypicals like Chlamydia, Legionella and Mycoplasma,

  22. Gram Negative Gram Positive Trimethoprim / Sulfa Aerobes Serratia Pseudomonas Acinetobactor Citrobactor Enterobactor Salmonella Shigella H. Flu Klebsiella E. Coli MRSA MRSE CA-MRSA VRE Strep Staph Klebsiella/E coli resistance increasing Oral Anaerobes Oral Anaerobes Bacteroides Clostridium Difficile First Line drug for Community Acquired MRSA Also covers Pneumocystis Carinii

  23. Gram Negative Gram Positive Vancomycin Aerobes Serratia Pseudomonas Acinetobactor Citrobactor Enterobactor Salmonella Shigella H. Flu Klebsiella E. Coli MRSA MRSE CA-MRSA VRE Strep Staph Oral Anaerobes Oral Anaerobes Bacteroides Clostridium Difficile

  24. Gram Negative Gram Positive Clindamycin Aerobes Serratia Pseudomonas Acinetobactor Citrobactor Enterobactor Salmonella Shigella H. Flu Klebsiella E. Coli MRSA MRSE CA-MRSA VRE Strep Staph Oral Anaerobes Oral Anaerobes Bacteroides Clostridium Difficile

  25. Gram Negative Gram Positive Metronidazole Aerobes Serratia Pseudomonas Acinetobactor Citrobactor Enterobactor Salmonella Shigella H. Flu Klebsiella E. Coli MRSA MRSE CA-MRSA VRE Strep Staph Oral Anaerobes Oral Anaerobes Bacteroides Clostridium Difficile Also Covers Trichomonas

  26. Gram Negative Gram Positive Linezolid Daptomycin Aerobes Serratia Pseudomonas Acinetobactor Citrobactor Enterobactor Salmonella Shigella H. Flu Klebsiella E. Coli MRSA MRSE CA-MRSA VRE Strep Staph Oral Anaerobes Oral Anaerobes Bacteroides Clostridium Difficile

  27. Gram Negative Gram Positive Aerobes Serratia Pseudomonas Acinetobactor Citrobactor Enterobactor Salmonella Shigella H. Flu Klebsiella E. Coli MRSA MRSE VRE Strep Staph Oral Anaerobes Bacteroides Clostridium Difficile Anaerobes

  28. Gram Negative Gram Positive Aerobes Serratia Pseudomonas Acinetobactor Citrobactor Enterobactor Salmonella Shigella H. Flu Klebsiella E. Coli MRSA MRSE VRE Strep Staph Oral Anaerobes Bacteroides Clostridium Difficile Anaerobes

  29. Gram Negative Gram Positive Aerobes Serratia Pseudomonas Acinetobactor Citrobactor Enterobactor Salmonella Shigella H. Flu Klebsiella E. Coli MRSA MRSE VRE Strep Staph Oral Anaerobes Bacteroides Clostridium Difficile Anaerobes

  30. Gram Negative Gram Positive Aerobes Serratia Pseudomonas Acinetobactor Citrobactor Enterobactor Salmonella Shigella H. Flu Klebsiella E. Coli MRSA MRSE VRE Strep Staph Oral Anaerobes Bacteroides Clostridium Difficile Anaerobes

  31. Gram Negative Gram Positive Aerobes Serratia Pseudomonas Acinetobactor Citrobactor Enterobactor Salmonella Shigella H. Flu Klebsiella E. Coli MRSA MRSE VRE Strep Staph Oral Anaerobes Bacteroides Clostridium Difficile Anaerobes

  32. Gram Negative Gram Positive Aerobes Serratia Pseudomonas Acinetobactor Citrobactor Enterobactor Salmonella Shigella H. Flu Klebsiella E. Coli MRSA MRSE VRE Strep Staph Oral Anaerobes Bacteroides Clostridium Difficile Anaerobes

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