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Immunology/Pharmacy Students Innate Immunity Lecture 4 Dr. Mohammad Odibate

Immunology/Pharmacy Students Innate Immunity Lecture 4 Dr. Mohammad Odibate Department of Microbiology and immunology Faculty of Medicine, Mu’tah University. Objectives. To understand the meaning of the innate immune response To study the different lines of the innate immune response

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Immunology/Pharmacy Students Innate Immunity Lecture 4 Dr. Mohammad Odibate

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  1. Immunology/Pharmacy Students Innate Immunity • Lecture 4 Dr. Mohammad Odibate Department of Microbiology and immunology Faculty of Medicine, Mu’tah University

  2. Objectives • To understand the meaning of the innate immune response • To study the different lines of the innate immune response • To understand the interaction between the different lines of the innate immune response • To study the association between NKs and innate immunity

  3. Cytotoxic T lymphocytes vs. NK lymphocytes

  4. Natural Killer cell NK cell NK cell Activating signal Activating protein Perforin and granzymes Inhibitory protein (Ly49) MHC 1 (self) Tumor cell Normal cell Lysis Survive

  5. Natural Killer cell NK cell NK cell Perforin and granzymes MHC 1 (nonself) Virally infected cell Incompatible transplanted tissue Lysis Lysis The activating in the absence of MHC1 will activate The NK cell to release the cytolytic proteins

  6. Natural Killer cell Natural Killer cells mediate antibody dependent mediated cell cytotoxicity (ADCC) APC Present these Mutated proteins to T cells Tumor cell Tumor cell produces abnormal (mutated proteins) APC uptakes cellular debris from damaged tumor cells Antibodies will be produced ,released into circulation, and Eventually bind to the tumor cell NK cell Perforin and granzymes NK has a receptor for the antibody Fc portion Tumor cell Tumor cell

  7. Innate immunity Third line defense Adaptive Immunity Second line defense Target

  8. In case of heavy infection macrophages will migration to regional lymph nodes to activate the adaptive immune response

  9. Levels of immunity

  10. Innate vs. adaptive immunity

  11. Innate vs. adaptive immunity

  12. Thank You

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