1 / 13

Wolfgang Schamel

Wolfgang Schamel. Systems Biology of T Cell Activation in Health and Disease:. Activation of a T Cell :. T-cell activation: recognize and eliminate infected cells (foreign peptides) ignore healthy self-tissues, although they are recognized (self-peptides).

taurus
Download Presentation

Wolfgang Schamel

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Wolfgang Schamel Systems Biology of T Cell Activation in Health and Disease:

  2. Activation of a T Cell :

  3. T-cell activation: • recognize and eliminate infected cells (foreign peptides) • ignore healthy self-tissues, although they are recognized (self-peptides) How is this discrimination achieved ?

  4. T-cell activation: • recognize and eliminate infected cells (foreign peptides) -> severe, persistent infections • ignore healthy self-tissues, although they are recognized (self-peptides) -> autoimmune diseases How is this discrimination achieved ?

  5. The affinity of MHCp determines the T cell stimulation outcome. T cell high affinity activation TCR MHCp 1 low affinity survival TCR MHCp 2 Nature 2006, Ed Palmer, CH partner of SYBILLA

  6. The affinity of MHCp determines whether an autoimmune disease develops. T cell presenting cell high affinity disease TCR MHCp 1 low affinity no disease TCR MHCp 2 Nature 2006, Lars Fugger, UK partner of SYBILLA

  7. -> what is the difference between signal A and signal B ? high affinity peptides (foreign) signal A activation of T cell low affinity peptides (self) signal B survival of T cell

  8. PLoS Comp. Biol. 2007, Burkhart Schraven and Jon Lindquist, D partners of SYBILLA

  9. Aim: To understand the intracellular network that governs T cell activation • SYBILLA: • EU-funded collaborative project • 17 partners (14 EU, 2 USA and 1 India) • 11.1 M Euros • 5 years (start: April 2008)

  10. Standardized quantitative protein data using a murine T cell line : Validation projects - Primary, naive T cells - Human T cells - Multiple sclerosis model Modelling projects - Dynamic models of many modules (incl. PTM, interaction & localization data) - Correlative models (incl. transcriptomics) - Extend and dynamize the Boolean network Interactomics project - identify the interaction partners of 200 proteins of the network after stimulation with foreign and self-peptide MHC

  11. EU FP7 proteome-based approach EU transcriptome-based approach US The Immunological Genome Project

  12. Webpage www.SYBILLA-T-cell.de Coordinator: Wolfgang Schamel, schamel@immunbio.mpg.de

More Related