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Lesson 4-5

Lesson 4-5. Introduction to Immunohematology. Immunohematology. Study of human blood groups Blood bank department Donor blood and blood transfusions Tissue typing Forensic studies Genetic studies Paternity tests See Table 4-7. History of Transfusion Medicine. William Harvey, 1628

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Lesson 4-5

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  1. Lesson 4-5 Introduction to Immunohematology

  2. Immunohematology • Study of human blood groups • Blood bank department • Donor blood and blood transfusions • Tissue typing • Forensic studies • Genetic studies • Paternity tests • See Table 4-7

  3. History of Transfusion Medicine • William Harvey, 1628 • James Blundell, 1818 • Karl Landsteiner, 1900, 1930 • First hospital blood bank, 1937 • Improvements after WW II

  4. History of Transfusion Medicine • Dramatic advancements from 1950s–1980s • AIDS • Discovered in 1980s • Caused major changes in blood donation and transfusion practices

  5. Standards and Regulation • Food and Drug Administration (FDA) • Regulates • American Association of Blood Banks (AABB) • Sets standards • Accredits

  6. Donor Blood • Donor requirements • Patient questionnaire • Patient physical • See Tables 4-8 and 4-9

  7. Donor Blood • Donor blood collection • Maintain sterility • 450 mL • CPDA: anticoagulant plus nutrients • Apheresis

  8. Donor Blood • Processing donor blood • ABO and Rh typing • Antibody screen • Tests for infectious agents • See Table 4-10

  9. Donor Blood • Components • Red blood cells • Platelets • Plasma, fresh frozen plasma (FFP)

  10. Storage of Donor Blood

  11. Synthetic Blood • Trauma victims • Perfluorochemicals • Cell-free stable hemoglobin

  12. Blood Bank Procedures • Most tests based on agglutination • ABO grouping • Rh typing • Compatibility testing • Tests for unusual antibodies • Safety • Quality assessment

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