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Elevated Prevalence of Asthma in Mexican-American Children of El Paso, TX

Elevated Prevalence of Asthma in Mexican-American Children of El Paso, TX. MD , FCCP. The aim of this study : Determine the prevalence of asthma among the population of Mexican origin in El Paso, Tx . Examine the association of atopy with asthma.

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Elevated Prevalence of Asthma in Mexican-American Children of El Paso, TX

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  1. Elevated Prevalence of Asthma in Mexican-American Children ofEl Paso, TX • MD, FCCP

  2. The aim of this study : Determine the prevalence of asthma among the population of Mexican origin in El Paso, Tx. Examine the association of atopy with asthma. Determine the association between intergenerational family asthma/atopy and childhood asthma/atopy. Analyze the influence of indoor pollution in the diagnosis of ashtma and atopy.

  3. Definition • Epidemiology • Prevalence • Intergenerational Risk • Maternal Risk • Indoor Risk • Ancestry

  4. Asthma • Chronic inflammatory disorder of the airway. • Recognized as a complex genetic disease mediated by exposures to environmental factors.

  5. Normal and Asthmatic Bronchiole

  6. Symptoms of Asthma • Coughing • Wheezing, a whistling sound • Shortness of breath • Chest tightness • Sneezing & runny nose • Itchy and inflamed eyes

  7. Asthma

  8. Asthma Epidemiology • 300 million affected worldwide • 22 million affected Americans • 1-18% global prevalence • 250,000 annual deaths worldwide

  9. Current Asthma Prevalence for Youth by Race/Ethnicity, Ages 5-17, 2005-2007 Centers for Disease Control and Prevention. National Center for Health Statistics. Health Data Interactive. www.cdc.gov/nchs/hdi.htm. [July 15, 2009]. Centers for Disease Control and Prevention. National Center for Health Statistics. Health Data Interactive. www.cdc.gov/nchs/hdi.htm. [July 15, 2009].

  10. Current Asthma Prevalence for Hispanic Youth,Ages 5-17, 2005-2007 Centers for Disease Control and Prevention. National Center for Health Statistics. Health Data Interactive. www.cdc.gov/nchs/hdi.htm. [July 15, 2009].

  11. Atopy • The genetic predisposition for the development of an increased immune response (IgE) to common allergens. • This results in symptoms of rhinoconjunctivitisor eczema.

  12. Association between Asthma and Atopy n= 1110 Venn Diagram diagramillustrating the association between asthma and atopy, The size of the circles and overlapping areas are are-proportional with respect to the total study.

  13. Odd Risks (ORs) for Lifetime Reported Asthma Among Parents and Grandparents

  14. Maternal Effect in Asthma

  15. Indoor Pollution Risk

  16. Ancestry Informative Markers ( AIMs) • Used to identify protective or detrimental effects in asthmatic conditions. • Indigenous ancestry has been shown to be a protective in the GALA study. • On the contrary , African ancestry increases the risk of asthmatic conditions in children.

  17. Ancestry of Latinos andAfrican Americans African Native American European “Mestizos” =

  18. Ancestry Informative Genetic Markers (AIMs) Ancestral Population Contemporary Population • SNPs • AIMs • SNPs • SNPs • SNPs SNP= Single Nucleotide Polymorphisms

  19. Genetic Origins of Latino Ethnic Groups Choudhry S, et. al: 2006

  20. Genetic diversity in Mexican populations Silva-Zolezzi I et al. PNAS 2009;106:8611-8616

  21. Conclusion • Both maternal and paternal disease state affects offspring disease, but the maternal asthma is the most potent contributor. • Children with a parent with asthma are about twice as likely to have asthma. • Those with a parent and grandparent with asthma are about five times more likely to have asthma. • Therefore there is a strong association between intergenerational family and childhood asthma.

  22. Conclusion • Our participants had a lower percentage of European markers and higher percentage of African markers than previously suspected • Wefound a lifetime prevalence of 26.1 % and a current asthma prevalence of 20.8 % among children in El Paso, Tx. • This asthma prevalence is two times the national average

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