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By: Victoria Roman Dr. Hobbs Biology P.6 May 15, 2004

Hemophilia. By: Victoria Roman Dr. Hobbs Biology P.6 May 15, 2004. Clotting Process. Types of Hemophilia. Gene Therapy. Treatments. History. 100. 100. 100. 100. 100. 200. 200. 200. 200. 200. 300. 300. 300. 300. 300. 400. 400. 400. 400. 400. 500. 500. 500. 500. 500.

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By: Victoria Roman Dr. Hobbs Biology P.6 May 15, 2004

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  1. Hemophilia By: Victoria Roman Dr. Hobbs Biology P.6 May 15, 2004

  2. Clotting Process Types of Hemophilia Gene Therapy Treatments History 100 100 100 100 100 200 200 200 200 200 300 300 300 300 300 400 400 400 400 400 500 500 500 500 500

  3. Clotting Process100 Points The body goes under three processes of clotting to do this.

  4. Clotting Process 100 Points What is stop the bleed?

  5. Clotting Process200 Points This process is the narrowing of blood vessels to decrease the flow of blood.

  6. Clotting Process200 Points What is vasoconstriction?

  7. Clotting Process 300 Points Platelets attach themselves to one another with this sticky material.

  8. Clotting Process300 Points What is von Willebrand’s factor?

  9. Clotting Process 400 Points What is the purpose of fibrin?

  10. Clotting Process 400 Points Fibrin, a thicky threadlike substance, forms a mesh over the platelets and pulls everything tightly together.

  11. Clotting Process 500 Points What are the three processes the body goes under to stop the bleeding?

  12. Clotting Processes 500 Points First is vasoconstriction, next is a platelet plug formation, lastly, a fibrin clot formation is built.

  13. Types of Hemophilia100 Points What is the most common type of Hemophilia?

  14. Types of Hemophilia100 Points What is Type A?

  15. Types of Hemophilia200 Points Hemophilia A is caused by a deficiency in what factor?

  16. Types of Hemophilia 200 Points What is Factor XIII?

  17. Types of Hemophilia 300 Points Hemophilia B was named after whom?

  18. Types of Hemophilia 300 Points Who is Steven Christmas?

  19. Types of Hemophilia 400 Points Hemophilia B is due to a lack of this certain factor.

  20. Types of Hemophilia 400 Points What is Factor IX.

  21. Types of Hemophilia 500 Points Hemophilia C affects how many people?

  22. Types of Hemophilia 500 Points What is one in every one hundred people?

  23. History100 Points Hemophilia is often called the “_____ disease” because is spread throughout the ruling families of Europe and Russia.

  24. History 100 Points What is the royal disease?

  25. History 200 Points • In 1932, R.G MacFarlane, a British pathologist, first learned that this unusual treatment helped blood clot.

  26. History 200 Points What is viper venom or commercialized “Stypen” which is still used today.

  27. History 300 Points • Who was Queen Victoria’s son that had hemophilia and died at the age of thirty-one from bleeding in the head after a minor fall?

  28. History 300 Points Who is Prince Leopold?

  29. History 400 Points In the early 1950’s, scientists used injections of blood plasma from what two animals to help hemophiliacs?

  30. History 400 Points What are cows and pigs?

  31. History 500 Points • Who performed the first successful blood transfusion for postoperative bleeding in a little boy with hemophilia?

  32. History 500 Points Who is Samuel Lane, an English physician?

  33. Gene Therapy 100 Points What are genes?

  34. Gene Therapy 100 Points What are specific sequences of bases that encode instructions on how to make proteins?

  35. Gene Therapy 200 Points Gene therapy is a technique for doing what?

  36. Gene Therapy 200 Points What is for correcting defective genes responsible for disease development?

  37. Gene Therapy 300 Points An abnormal gene could be swapped for a normal gene through this approach.

  38. Gene Therapy 300 Points What is homologous recombination?

  39. Gene Therapy 400 Points • Factors that have kept gene therapy from becoming an effective treatment for genetic diseases are immuneresponse, problems with viralinfectors, multigene disorders, and ______________.

  40. Gene Therapy 400 Points What is the short-lived nature of gene therapy?

  41. Gene Therapy500 Points Name four of the different types of viruses used as gene therapy vectors.

  42. Gene Therapy 500 Points What are retroviruses, adenoviruses, adeno-associated viruses, and herpes simplex viruses?

  43. Treatments 100 Points What four treatment preparations that contain clotting factor are used by hemophiliacs?

  44. Treatments 100 Points What are whole blood, plasma, cryoprecipitate, and factor concentrates? (also desmopressin or DDAVP and Gene Therapy)

  45. Treatments 200 Points What are some drawbacks for cryoprecipitate?

  46. Treatments 200 Points What are that it is less safe from viral contamination than concentrates and is harder to store and administer?

  47. Treatments 300 Points What are some drawbacks in using whole blood in the treatment of hemophilia?

  48. Treatments 300 Points What are that the whole blood must be fresh, the red cells most be compatible with the recipient, and the possibility of overloading the circulation and causing the heart to fail?

  49. Treatments 400 Points In plasma, the life of the clotting factor is preserved by making this product.

  50. Treatments 400 Points What is fresh frozen plasma or FFP?

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