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Protein Synthesis

Protein Synthesis. Translation. Translation Overview. One codon  One amino acid. Transfer RNA. Ribosomes. Peptide bond formation. Codon-anticodon matching. T. A. C. G. G. C. A. A. A. C. T. C. C. G. G. A. C. T. A. U. G. C. C. G. U. U. U. G. A. G. G. C. C.

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Protein Synthesis

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  1. Protein Synthesis Translation

  2. Translation Overview One codon One amino acid

  3. Transfer RNA

  4. Ribosomes • Peptide bond • formation • Codon-anticodon • matching

  5. T A C G G C A A A C T C C G G A C T A U G C C G U U U G A G G C C U G A A T G C C G T T T G A G G C C T G A Transcription/Translation

  6. E P A A U G G A A C C A A U G C C G U U U U A G G C C U G A Peptidyl Site Met Phe Pro Exit Site Aminoacyl Site

  7. E P A G A A G A C A U G C C G U U U U A G G C C U G A Met Pro Phe Pro

  8. Wobble • Only 45 different tRNA molecules exist • Pairing of the anticodon with the third base of the codon is less specific

  9. Protein Processing • Ribosome type depends on ultimate destination of polypeptide

  10. Protein Processing • Signal peptide region • ~ 20 peptides at start of PPChain • Binds to SRP as rest of PPChain is translated • Signal Recognition Particle • Carries whole translation complex to ER membrane • PPChain is fed into cisterna

  11. DNA Function Review • What are the three sites in a ribosome? • Spliceosome:Intron::_____:_____ • How is location of translation related to the eventual use of its product? • What is wobble?

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