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Molecular markers for susceptibility to heat intolerance

Molecular markers for susceptibility to heat intolerance. Maj. Yuval Heled, PhD The Institute of Military Physiology Heller Institute of Medical Research The IDF Medical Corps Israel. Genetic map for health and performance. Findings the best athletes? Preventing diseases?.

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Molecular markers for susceptibility to heat intolerance

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  1. Molecular markers for susceptibility to heat intolerance Maj. Yuval Heled, PhD The Institute of Military Physiology Heller Institute of Medical Research The IDF Medical Corps Israel

  2. Genetic map for health and performance • Findings the best athletes? • Preventing diseases?

  3. Vision (or science fiction?) Using one small blood draw will assist in: • Prevention • Diagnosis • Prognosis • Intervention (nutrigenomics, supplements, specific training…….)? • Selection…?!!!

  4. Candidate gene approach

  5. Angiotensin converting enzyme (ACE) polymorphism and the physiological response to heat challenge Heled Y et al: J Appl Physiol, 2004;97:72-6

  6. The differences in physiological parameters changes during exposure to heat tolerance test between the two ACE genotype groups Heled Y et al: J Appl Physiol, 2004;97:72-6

  7. P<0.05 Heled Y et al: J Appl Physiol, 2004;97:72-6

  8. P<0.05 Heled Y et al: J Appl Physiol, 2004;97:72-6

  9. 1200 C+ (n = 77) 960 GG (n = 62) 720 480 240 0 Pre Post 48 Hr 72 Hr IL-6 Genotypes and CK response to exercise test * * Creatine Kinase (IU/L) * * * p<0.03 Heled Y, Deuster P: in publication

  10. HSP70-2 Genotypes and CK response to exercise test * p<0.03 Heled Y, Deuster P: in publication

  11. Conclusions • Molecular markers may assist in preventing physiological injuries • Genetic/proteomic map of trainability and susceptibility is a future challenge

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