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Pertussis and Pertussis Vaccine

Pertussis and Pertussis Vaccine. Epidemiology and Prevention of Vaccine-Preventable Diseases National Immunization Program Centers for Disease Control and Prevention. Dr Esteghamati EPI Manager. Pertussis. Highly contagious respiratory infection caused by Bordetella pertussis

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Pertussis and Pertussis Vaccine

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  1. Pertussis and Pertussis Vaccine Epidemiology and Prevention of Vaccine-Preventable Diseases National Immunization Program Centers for Disease Control and Prevention Dr Esteghamati EPI Manager

  2. Pertussis • Highly contagious respiratory infection caused by Bordetella pertussis • Outbreaks first described in 16th century • Bordetella pertussis isolated in 1906 • Estimated 285,000 deaths worldwide in 2001

  3. Bordetella pertussis • Fastidious gram-negative bacteria • Antigenic and biologically active components: • pertussis toxin (PT) • filamentous hemagglutinin (FHA) • agglutinogens • adenylate cyclase • pertactin • tracheal cytotoxin

  4. Pertussis Pathogenesis • Attachment to cilia of ciliated epithelial cells in respiratory tract • Pertussis antigens allow evasion of host defenses (lymphocytosis but impaired chemotaxis) • Local tissue damage in respiratory tract • Systemic disease may be toxin mediated

  5. Pertussis Clinical Features • Incubation period 5-10 days (up to 21 days) • Insidious onset, similar to minor upper respiratory infection with nonspecific cough • Fever usually minimal throughout course

  6. Pertussis Clinical Features • Catarrhal stage 1-2 weeks • Paroxysmalcough stage 1-6 weeks • Convalescence Weeks to months

  7. The forgotten killer VPD

  8. Pertussis in Adults • Accounts for up to 7% of cough illnesses per year • Disease often milder than in infants and children • Adults often source of infection for children

  9. Pertussis Complications* Condition Pneumonia SeizuresEncephalopathy Death Hospitalization Percent reported 5.2 0.8 0.1 0.2 20 *Cases reported to CDC 1997-2000 (N=28,187)

  10. Pertussis Complications by Age *Cases reported to CDC 1997-2000 (N=28,187)

  11. Pertussis Epidemiology • Reservoir Human Adolescents and adults • Transmission Respiratory droplets Airborne rare • Communicability Maximum in catarrhal stage Secondary attack rate up to 80%

  12. Whole-Cell Pertussis Vaccine • Developed in mid-1930s and combined as DTP in mid-1940s • 70%-90% efficacy after 3 doses • Protection for 5-10 years • Local adverse reactions common

  13. Acellular Pertussis Vaccine (DTaP) • Purified "subunit" vaccines • Intended to reduce adverse reactions • Licensed for fourth and fifth doses in 1991 • Licensed for full series in 1996

  14. School Entry (fifth) Dose • Fifth dose recommended when 4th dose given before age 4 years • Infanrix and Tripedia licensed for 5th dose after DTaP series

  15. Interchangeability of Different Brands of DTaP Vaccine • Series should be completed with same brand of vaccine if possible • Limited data suggest that “mix and match” DTaP schedules do not adversely affect safety and immunogenicity • Use different brand of DTaP if necessary

  16. TriHIBit • DTaP-Hib combination • Do not use for primary immunization at 2, 4, or 6 months of age • May be used as the booster dose of the Hib series at >12 months of age following any Hib vaccine* *booster dose should follow prior dose by >2 months

  17. Pediarix • DTaP – Hep B – IPV combination • Approved for 3 doses at 2, 4 and 6 months • Not approved for booster doses • Licensed for children 6 weeks to 7 years of age

  18. Pertussis Vaccination of Children Who Have Recovered From Pertussis • If documented disease, do not need additional doses of pertussis vaccine • Satisfactory documentation of disease: • recovery of B. pertussis on culture, OR • typical symptoms and clinical course when epidemiologically linked to a culture-proven case

  19. Pertussis Vaccine in Adults • No pertussis vaccine licensed for use in adults in the United States • Acellular pertussis vaccine safe and immunogenic in adults • Impact on disease or transmission unknown • Not routinely recommended at this time

  20. DTaP Adverse Reactions • Local reactions • Low grade fever • More severe adverse reactions uncommon • Local reactions more common following 4th and 5th doses

  21. Adverse Reactions Following the 4th and 5th DTaP Dose • Local adverse reactions and fever increased with 4th and 5th doses of DTaP • Reports of swelling of entire limb • Extensive swelling after 4th dose NOT a contraindication to 5th dose

  22. DTaP Contraindications • Serious allergic reaction to vaccine component or following prior dose • Encephalopathy occurring within 7 days after vaccination not due to another identifiable cause

  23. DTaP Precautions (Warnings)* • Moderate or severe acute illness • Temperature >105 F (40.5 C) or higher within 48 hours with no other identifiable cause • Collapse or shock-like state (hypotonic-hyporesponsive episode) within 48 hours • Persistent, inconsolable crying lasting >3 hours, occurring within 48 hours • Convulsions with or without fever occurring within 3 days *may consider use in outbreaks

  24. Clinical case definition A case diagnosed as pertusis by a physician Or a person with a cough lasting at least 2 weeks with at least one of the following • Paroxysm of cough • Inspiratory whooping • Post tussive vomiting

  25. Criteria for lab confirmation • Isolation of bordetella pertusis • Or detection of genome sequences by PCR • Or rising titer

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