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STROKE STATS

STROKE STATS. Third leading cause of death 160 000 deaths a year 731 000 strokes a year 4 400 000 stroke survivors Leading cause of adult disability . Source: Stroke Facts: 1999 NSA. Prevalence of stroke by age and sex United States: 1988-94.

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STROKE STATS

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  1. STROKE STATS • Third leading cause of death • 160 000 deaths a year • 731 000 strokes a year • 4 400 000 stroke survivors • Leading cause of adult disability Source: Stroke Facts: 1999 NSA

  2. Prevalence of stroke by age and sexUnited States: 1988-94 Heart Disease and Stroke Statistics – 2003 Update. Dallas, TX: AHA; 2002.

  3. 5 - 7 times (includes death) 3 - 4 times (includes TIA) 9 times 2 - 3 times (includes angina and sudden death) 4 times (includes fatal MI & other CHD death) 2 - 3 times (includes TIA) Increase in risk MI Stroke Initial event Coronary artery Myocardial infarction Cerebrovascular Ischemic stroke Peripheral vascular PAD Adult Treatment Panel II National Cholesterol Education Program Circulation 1994; 89:1333-1435Kannel WB. J. Cardiovascular Risk 1994; 1:333-339 Wilterdink et al., Arch Neurol 1992;49:857-863 Criqui et al., N. Engl. J. Med. 1992; 326:381-386

  4. Long-term risk of a cardiovascular event following a TIA CV death, MI or stroke CHD death or MI Any stroke Clark et al. J Neurol Neurosurg Psychiatry 2003;74:577-580

  5. 100 91% 80 85% 75% 66% 60 40 20 21% 0 >50 13-19 20-29 30-39 40-49 Prevalence of IVUS-detected atherosclerotic coronary artery disease Prevalence (%) 262 healthy donor heart transplants Age (years) Tuzcu EM. Circulation 2001;103:2705

  6. Stenosis severity by angiography of atherosclerotic disease preceding MI # patients Pre-MI Stenosis 100 200 14% >70% 50-70% 18% < 50% 68% 0 0 Ambrose 1985 Little 1988 Nobuyoshi 1991 Giroud 1992 All E Falk, PK Shah, V Fuster. Circulation 1995;92:657

  7. Clinical presentation of atherosclerosis: Just the tip of the iceberg Clinical atherosclerosis CAD CVA PAD Subclinical Hyperinsulinemia Dyslipidemia Inflammation Platelet activation Hypercoagulable Endothelial dysfunction Oxidative stress

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