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Integrating Cells Into Tissues

Integrating Cells Into Tissues. Dawn M. Ford. A Brief Overview. Cells aggregate into 5 main classes of tissue Muscular Nervous Connective Epithelial Blood Tissues are assembled to form organs. Cell Adhesion.

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Integrating Cells Into Tissues

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  1. Integrating Cells Into Tissues Dawn M. Ford

  2. A Brief Overview • Cells aggregate into 5 main classes of tissue • Muscular • Nervous • Connective • Epithelial • Blood • Tissues are assembled to form organs

  3. Cell Adhesion • Allows cells to aggregate & provides means for bidirectional transfer of information • Cell-to-cell adhesion • Cell adhesion molecules (CAMs) • Cell-matrix adhesion • Adhesion receptors bind to extracellular matrix (ECM)

  4. Cell-To-Cell Adhesion

  5. CAMs • Homotypic or heterotypic adhesion • Homophilic or heterophilic binding • Broadly distributed or clustered in cell junctions • Long lasting adhesions or transient

  6. Four Major CAM Families • Cadherins • Ca2+ dependent interactions • Selectins • Recognize glycoproteins & glycolipids • Immunoglobulin-Superfamily • Ca2+ independent interactions • Integrins • Multi-functional

  7. Cell-Matrix Adhesion

  8. Extracellular Matrix • Proteoglycans • Collagens • Soluble Multiadhesive Matrix Proteins

  9. The Big Picture • Adhesions very important in animal tissues • Formation • Composition • Architecture • Function • Adhesion molecules are highly conserved proteins • Complex organisms have depended on their evolution

  10. The End La Fin Das Ende Het Eind l'estremità

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