A Revolutionary Approach to Clear Heavy Metals & Toxins

1. A Revolutionary Approach to Clear Heavy Metals & Toxins • All of us are carrying around a LIFETIME of accumulated TOXINS!!! • There is now a simple, scientific and very effective means for substantially reducing your risk of Toxic Induced Chronic Degenerative Diseases!!!

2. “A growing body of literature suggests an association between toxicant exposure and the etiology of a number of chronic Conditions.” The Role of Detoxification in the Prevention of Chronic Degenerative Diseases BY DEANN J. LISKA, PH.D. of Chronic Degenerative Diseases BY DEANN J. LISKA, PH.D. • Abnormal pregnancy outcomes • Atherosclerosis • Broad mood swings • Cancer • Chronic fatigue syndrome • Chronic immune system depression • Contact dermatitis • Fatigue • Fertility problems • Fibromyalgia • Headaches • History of increasing sensitivity to exogenous exposures, odors, or medications • Joint pain • Kidney dysfunction • Learning disorders • Memory loss • Mineral imbalances (particularly zinc and calcium) • Multiple chemical sensitivities • Muscle pain and weakness • Nonresponsive or recurrent yeast infections • Panic attacks • Parkinson's disease • Tinnitus • Unusual responses to medications or supplements •Worsening of symptoms after anesthesia or pregnancy

3. TOXIC EFFECTS OF GENETICALLY MODIFIED ORGANISMS“GMO” OR “GM” FOOD Weare confrontedwith what is undoubtedly the single most potent technology the world has ever known - more powerful even than atomic energy. Yet it is being released throughout our environment and deployed with superficial or no risk assessments - as if no one needs to worry an iota about its unparalleled powers to harm life as we know it - and for all future generations.Nathan Batalion, ND www.rawwisdom.com/genetically%20modified%20food

4. “statins are nothing more than isolated poisons derived from the fungus known as red yeast rice” “Nowhere in the History of man has an acknowledged poison been touted as a daily vitamin for every man woman and child.” Reuter Health News Wednesday, May 23, 2007

5. Non- GMP certified supplements can be toxic!!! • “Of the 21 brands of multivitamins on the market in the US and Canada, selected by ConsumerLab.com and tested by by independent laboratories, just 10 met the stated claims on their labels or satisfied other quality standards.” • “In the report, test showed that the Vitamin Shoope womens product conatined 15.3 micrograms of lead per daily serving of two daily tablets. This amount of lead is more than 10 times the amount permitted wothout a warning in California.” • www.msnbc.msn.com/id/16655168/below

6. WebMD with AOL Health • In a study of newborn blood released by the Environmental Working group, an average of 200 industrial chemicals and pollutants were found in umbilical cord... • Eighteen different forms of dioxin were also found in the samples • www.my.webmd.com/content/article/10/8/109035.htm

7. Scientist have found TOXIC compounds planet wide, in polar bears in the Artic, cormorants in England and killer whales in the Pacific.

8. Dangers of Visceral Adipose Tissue Belly Fat “Fat is a major source of silent inflammation. It is a toxic waste dump full of Arachidonic Acid and Toxins.” Barry Sears, Ph.D.

9. Research published in the InternationalJournal of Obesity indicates that liver toxicity can often lead to excess body fat accumulation, and moderately obese people frequently suffer from liver dysfunction “Due to the overwhelming evidence linking excess body fat to an overstressed liver cleansing and supporting your liver may be your ticket to a healthier metabolism.” Brad J. King, MS, MFS, is a nutritional researcher and author

10. Toxins from the environment and diet usually can lead bodily stress and dis-ease Continuous exposure to dietary and environmental toxins may lead to an impairment in the ability of patients to metabolize and clear damage causing compounds from their body

11. We are routinely exposed to heavy metal toxins through food, ground water, industrial waste and exposure to industrial environments. Exposure to heavy metal toxicants is almost unavoidable in today’s world

12. Elevated toxic burden is related to a number of different chronic conditions “There were striking dose-response relations between serum concentrations of six selected POP’s (persistent organic pollutants) and the prevalence of type 2 diabetes. The strong association could offer a compelling challenge to future toxicological studies.” Diabetes Care 2006; 29: 1638-43.

13. PCB production was banned in the 1970s due to the high toxicity of most PCB congeners and mixtures. PCBs are classified as persistent organic pollutants which bioaccumulate in animals. Many POPs are currently or were in the past used as pesticides. Others are used in industrial processes and in the production of a range of goods such as solvents, polyvinyl chloride, and pharmaceuticals.[1]

14. Elevated toxic metal burden affects all organ systems Toxicity, Heavy Metals Soghoian S, MD, et al Department of Emergency Medicine, State University of New York Downstate Medical Center Background: Heavy metal toxicity represents an uncommon, yet clinically significant, medical condition. If unrecognized or inappropriately treated, heavy metal toxicity can result in significant morbidity and mortality. The periodic table contains 105 elements, of which 80 are considered metals. Toxic effects in humans have been described for less than 30 of these. Many metals are essential to biochemical processes, and others have found therapeutic uses in medicine. Iatrogenic metal toxicity may occur with bismuth, gold, gallium, lithium, and aluminum species. Intentional or unintentional ingestion of arsenic has been notorious as a means of suicide and homicide. However, occupational exposure to heavy metals has accounted for the vast majority of poisonings throughout human history. Hippocrates described abdominal colic in a man who extracted metals, and the pernicious effects of arsenic and mercury among smelters were known even to Theophrastus of Erebus (370-287 BC). The classic acute occupational heavy metal toxicity is metal fume fever (MFF), a self-limiting inhalation syndrome seen in workers exposed to metal oxide fumes. MFF, or “brass founders ague,” “zinc shakes,” “Monday morning fever” as it is variously known, is characterized by fever, headache, fatigue, dyspnea, cough, and a metallic taste occurring within 3-10 hours after exposure. The usual culprit is zinc oxide, but MFF may occur with magnesium, cobalt, and copper oxide fumes as well. A neutrophil alveolitis ensues, with hypoxia, reduced vital capacity, and diffuse bilateral infiltrates seen on radiographs. The pathophysiology of MFF appears to be a direct toxic irritation. Treatment is supportive and effects generally resolve within 24 hours. The diagnosis of MFF is based on a history of exposure and must be clearly differentiated from the true chemical pneumonitis that occurs after exposure to metal fumes from cadmium, manganese, mercury, and nickel. These exposures are clinically indistinguishable from MFF in the early stages but tend to progress to ARDS and cause significantly more morbidity and mortality. Toxic effects from chronic exposure to heavy metals are far more common than acute poisonings. Chronic exposure may lead to a variety of conditions depending on the route of exposure and the metabolism and storage of the specific element in question. For example, chronic exposure to cobalt dust has been associated with the development of pulmonary fibrosis that can lead to cor pulmonale. This hard metal pneumoconiosis has been described for other metal dusts. Chronic inhalation of high levels of cadmium also causes both fibrotic and emphysematous lung damage, but it also has major effects in bone and “Nearly all organ systems are involved in heavy metal toxicity; however, the most commonly involved organ systems include the central nervous system, peripheral nervous system, gastrointestinal, hematopoietic, renal, and cardiovascular.” http://www.emedicine.com/EMERG/topic237.htm

15. How do you recognize the symptoms of elevated toxicity in your body? • Some EARLY warning signs are: • Generalized muscle aches • Chronic fatigue • Fibromyalgia • Food allergies or chemical sensitivities

16. Additional indications that may be linked to elevated heavy metal burden • Some EARLY warning signs of heavy metal toxicity are: • Difficulty concentrating, irritability, headache • Lethargy, fatigue, weakness (#1 physical complaint) • Abdominal pain, tremors, • Kidney distress, elevated liver enzymes

17. Simple in-office surveys and tools that help us help identify patients in need • Simple diagnostics to evaluate toxicity in our patients • Detoxification Questionnaire • Bio Impedance Analysis • (Phase Angle and ICW Vs. ECW) • Urinary pH testing • Hair analysis

18. Use the detoxification questionnaire to qualify your patients’ needs • Detoxification Questionnaire • Quantifies patient symptoms (MSQ) • Identifies Toxicant Tolerability (XTT) • Simple metric to track patient improvement

19. Use the established MSQ to quantify symptoms • Medical Symptoms Questionnaire (MSQ) • Identifies symptoms in most body systems • Quantifies patient’s level of symptoms • Provides a simple metric to track patient improvement

20. pH testing aids in identifying our patients that may benefit from increased urinary alkalinity • Increased urinary alkalinity has been associated with increased rates of toxin excretion • Screen patients that may need additional support to excrete toxins We always recommend alkalizing support for patients with urinary pH below 6.6

21. By far the majority of toxins and toxic drugs are lipid soluble: Therefore, to be efficiently and safely removed via urine must be converted to a non-toxic water-soluble molecule during metabolism

22. Liver - The Detox Machine • Filters 2 quarts of blood every minute • Removes and alters substances • Prepares them for elimination

23. Specific nutrients are required to support all three phases of detoxification Metabolic detoxification improves the process of biotransformation and an alkaline urinary pH supports clearance of toxins Phase III Phase I Phase II Increased alkalinity supports excretion Helps to balance clearance enzymes

24. Phase I enzymes activate toxins in preparation for biotransformation L-Cysteine, Magnesium and other nutrients support proper expression of Phase I CYP450 enzymes Phase I Cytochrome P450 enzymes add reactive functional groups to fat-soluble toxins Reactive Intermediary Phase I Toxin Phase II Functionalization Conjugation

25. Phase II enzymes neutralize the activated toxin in preparation for elimination Glycine, taurine, sodium sulfate and glutathione precursors support the creation of Phase II enzymes Phase II The functional groups are then reacted with conjugation molecules to neutralize the toxins and make them water soluble Reactive Intermediary Neutralized Toxin Phase I Phase II Functionalization Conjugation

26. Elimination of toxins is supported by an alkaline urinary pH Potassium citrate increases urinary alkalinity which supports excretion of biotransformed toxins Neutralized Toxin Neutralized Toxin Phase I Phase III Phase II Alkaline urine supports excretion Functionalization Conjugation

27. There is a demonstrated need for a safer, more convenient method of removing heavy metals • Intravenous Chelation Therapy • EDTA • Typically heavy metals and atherosclerosis • Has not been shown effective in oral dosing • Side effects: Depletion of vitamins and minerals, including B vitamins, vitamin C, and magnesium. • Other side effects that have been reported include low blood sugar, diminished calcium levels, headache, nausea, dangerously low blood pressure, kidney failure, organ damage, irregular heartbeat, and seizures.

28. A new approach: stimulate the body’s natural ability to remove heavy metals Metallothionein • One of the most important detoxification proteins in all species • In absence of heavy metals, its primary role is to transport zinc and copper • Protection against and elimination of toxic metals by metallothionein is well-described in literature Andrews GK. Regulation of metallothionein gene expression by oxidative stress and metal ions. Biochem Pharmacol 2000;59(1):95-104. Lichtlen et al.. Bioessays. 2001;23(11):1010-7.

29. Andrews GK. Regulation of metallothionein gene expression by oxidative stress and metal ions. Biochem Pharmacol 2000;59(1):95-104. Lichtlen et al.. Bioessays. 2001;23(11):1010-7. Natural proteins designed to transport and eliminate metals from cells Metallothioneins • Known to efficiently bind several toxic metals (particularly Cadmium and Mercury) and act as a transporter of toxic metals to the liver or kidneys for conjugation and excretion • Prevents reaction of toxic metals with other biomolecules, thus attenuating their toxicity Sources of heavy metals include seafood, groundwater, smoking, dental amalgams, pesticides and industrial exposure

30. We can expect exceptional regenerative outcomes with a nutrigenomic approach A complete system for detoxification (Direct) Diet & Medical Food (Indirect) Metabolism SKRMS: Modulate cell signals Gene Expression Key Nutritional Support for liver and kidneys Cellular Expression

31. A revolutionary mechanism for heavy metal detoxification The excretion of toxic metals is governed by a complex chain of interwoven activities: • Phytonutrients up-regulates expression of MTF-1 (Metal-activated transcription factor-1) • MTF-1 induces creation of metallothionein (MT) in messenger RNA • Induced metallothionein (MT) bind to metals within the cell • Once metal is mobilized by MT, it is transported through the cell membrane and transported to the liver for Phase II detoxification and excretion through urine or feces

32. Study patients experienced a significant increase in the excretion of metals • All patients began with mercury levels below detectable limits • Two patients experienced a significant increase in mercury excretion Elimination of arsenic increased 124% Elimination of lead increased 200% Mercury Elimination Through Urine Metabolism of essential minerals was not significantly impacted in study patients* *manganese was the one exception, consider additional supplementation during program. Increase over baseline

33. No significant side effects were seen in study patients • No changes in basic labs including hematology, electrolytes, and liver and kidney function tests • Two subjects had minor symptoms: • One subject with history of migraines experienced a migraine and GI upset • One subject experienced mild headache

34. Conclusions from study and clinical guidelines Combination of Polyphenol-rich hops, andrographis, curcumin and zinc • Resulted in a significant increase in the expression of metallothionein • Increases excretion of clinically relevant toxic metals (with minimal effect on nutrient compounds)

35. Research indicates this clinical breakthrough achieves dramatic results • This revolutionary approach has shown clinically to support and eliminate the following symptoms of heavy metal toxicity: • Fatigue, lethargy, muscle weakness • Difficulty concentrating, irritability, headache • Kidney distress, elevated liver enzymes • Positive lab or hair analysis for heavy metals Other considerations: • Can be used to compliment a comprehensive metabolic detoxification program • Some patients may experience mild headache • Additional manganese supplementation may be needed Metagenics Functional Medicine Research Center dosage guidelines 3 tablets twice daily for 30 to 60 days

36. The Intestinal Tract • A Natural Barrier to Toxic Substances • “Leaky Gut Syndrome” - passage of toxic substances into the body

37. Strategies to Prevent “Leaky Gut” • Balance microflora (“good” bacteria) • Limit use of NSAIDs • Enlist nutritional support • Minimize use of alcohol, caffeine, processed foods and additives • Manage stress

38. Promote Balanced Microflora • Probiotics • Lactobacillus acidophilus • Bifidobacterium • Prebiotics • Fructooligosaccharides – honey, onions, bananas, oats

39. Foods for Detoxification • Cruciferous vegetables • Broccoli, cabbage, bok choy, arugula, cauliflower • Limonene-containing fruits • Orange, tangerine, lemon (not grapefruit)

40. Nutrients for Detoxification • Magnesium • Copper • Zinc • Vitamin C • Vitamin B family • Protein

41. Core Protocols for Comprehensive Detoxification Metabolic Detoxification Alkalizing support for detoxification • 2 scoops twice daily as recommended in Quick Start guide • Choose 10 or 28 day program based upon need • Some people may need to be introduced to the Medical Food slowly Heavy Metal Detoxification Polyphenol-rich hops, Andrographis, Curcumin, Zinc • 3 tablets twice daily • Continue therapy for 30 to 60 days • Use in conjunction with a comprehensive metabolic detoxification program, or as a stand-alone therapy

42. You can expect increased NRG and a dramatic increase in health with a clinically proven approach to detoxification • Research Summary • 17 Years of clinical testing with tens of thousands of patients • Published clinical studies demonstrating efficacy • Numerous case studies establishing effectiveness in treating toxic-related symptoms • Significant reduction in patient symptoms is typical • Significant improvement in patients’ condition in just four weeks۰ Fibromyalgia Fibromyalgia, Peripheral Neuropathy, and Insomnia Case Studies: MET1504, MET1505