Commercial awareness of bioscience industry Dr. Daria Olijnyk Sistemic Ltd.

1. Commercial awareness of bioscience industry Dr. Daria Olijnyk Sistemic Ltd.

2. Sistemic Ltd. - Corporate overview • Venture capital-funded (2009) • Product development and service company • HQ and Labs - Glasgow (UK); North American Sales Office – Boston (US) • broad IP portfolio of miRNA-based products robust microRNA profiling customised multilayered statistical and contextual analysis Designed to identify the key miRNAs (kmiRs™) – biomarkers of phenotype, together with their underlying biological interpretation to study changes in biological systems

3. About miRNAs • Non-coding RNAs • Short (17-24nt), endogenous • Single stranded • Regulate gene expression by transcriptional silencing and/or mRNA degradation • 1898 human miRNAs (miRBase v.18) • Target ~60% of human genes • miRNA signature is: • - Reproducible • - Highly conserved between species • - Tissue/cell type/biological process specific • - Discriminative of healthy and diseased tissue • - Analytically robust • - Potent in delivery of reliable biomarkers Joshi S. R., et al. MicroRNAs-control of essential genes : implications for pulmonary vascular disease. Pulmonary Circulation. 1 (3) 357-364 2011

4. About Sistemic Ltd. Methodology SistemQC™ SistemRNA™ • Stem Cell Research • Cell Therapy • Bio processing • Drug Development

5. The utility of Sistemic Methodology Novel, Potent and Broadly Applicable SistemQC™ SistemRNA™ Cell Characterisation/Cell QC Drug Discovery • Identity markers • Potency assays • Purity assessment • Differentiation staging • optimisation/monitoring • Benchmarking cell models • QC of batch-to-batch consistency • Positioning/Repurposing • Predictive and Investigative Toxicology • Discover robust companion biomarkers

6. The utility of Sistemic Methodology Novel, Potent and Broadly Applicable SistemQC™ SistemRNA™ Cell Characterisation/Cell QC Drug Discovery • Identity markers • Potency assays • Purity assessment • Differentiation staging • optimisation/monitoring • Benchmarking cell models • QC of batch-to-batch consistency • Positioning/Repurposing • Predictive and Investigative Toxicology • Discover robust companion biomarkers

7. About SistemQC™ Cell identity and cell model evaluation Private and confidential

8. The utility of Sistemic Methodology Novel, Potent and Broadly Applicable SistemQC™ SistemRNA™ Cell Characterisation/Cell QC Drug Discovery • Identity markers • Potency assays • Purity assessment • Differentiation staging • optimisation/monitoring • Benchmarking cell models • QC of batch-to-batch consistency • Positioning/Repurposing • Predictive and Investigative Toxicology • Discover robust companion biomarkers

9. About SistemQC™ Adult mesenchymal stem cell discrimination Private and confidential

10. Rapid growth at Sistemic continues Commercial Sector Sales continue to grow Customer base expanded over 3 continents

11. Customer base

12. Customer Base Private and confidential

13. Rapid growth at Sistemic continues Research and Development Industrial collaborations Commercial Sector Academic collaborations Sales continue to grow Internal R&D Customer base expanded over 3 continents

14. Industrial Collaborations

15. Rapid growth at Sistemic continues Research and Development Industrial collaborations Commercial Sector Academic collaborations Sales continue to grow Internal R&D Customer base expanded over 3 continents Company profile Teaching Plan to increase the number of staff Joined PhD studentship BSc student placements Plan to move to new premises

16. Career progression FROM ACADEMIA TO INDUSTRY • Becoming aware and able to identify transferable skills that you gain throughout your academic career and life experiences

17. You will be surprised... COMMUNICATION, MANAGMENT AND LEADERSHIP SKILLS BSc in Biotechnology Erasmus-Socrates placement • proactive • determination Bar supervisor at Blanket night club Postgraduate Teaching Assistant and Tutor PhD in Pubertal Mouse Mammary Gland Development Research Technician for MD Biosciences Inflammation Discovery Sciences MRes in Biomedical and Life Sciences Mentoring Charity work • time management skills • familiar with immunological techniques • used in drug development • ability to work under stress • ability to meet deadlines • team working skills • communication skills • good customer care • reliability and punctuality • broad set of project/time • management skills • broad set of written and oral • communication skills • organisation skills • leadership skills • team working skills and ability to work • unsupervised

18. Career progression FROM ACADEMIA TO INDUSTRY • Becoming aware and able to identify transferable skills that you gain throughout your academic career and life experiences • Be enthusiastic, flexible and prepared to spend time learning • and polishing a new set of skills needed to adapt a different way of • working/carrying out research

19. I still learn every day... • The way you talk about your research and results • Higher level of documentation • - lab book – evidence for patenting (very accurate, signed off by another person • every day, be aware not to put any personal observations that may prove • incorrect but may jeopardise patent application) • - client sample/analysis – standardised way of recording information • Experiments are carried out according to accepted/standard protocols proprietary to the company (SSOP) • Another layer of communication skills – speaking to customers, company • representatives, company marketing • Small-medium company allows interactions with multidisciplinary team - often • you will be involved in a variety of different tasks

20. Career progression FROM ACADEMIA TO INDUSTRY • Becoming aware and able to identify transferable skills that you gain throughout your academic career and life experiences • Be enthusiastic, flexible and prepared to spend time learning • and polishing a new set of skills needed to adapt a different way of • working/carrying out research • Be open minded and versatile and not afraid to step out of your comfort zone • “ To progress your carrier in industry you have to think about science • from a broader, more managerial, business-like perspective” • Jim Reid Chairman/CEO at Sistemic

21. There is hope! o • Life Sciences has been identified by Government and Scottish • Enterprise as a key sector for Scottish economy • A lot of financial support for Life Sciences sector in Scotland • Scotland - one of the largest Life Sciences clusters in Europe (560 companies) • The number of jobs in Life Sciences sector are sill growing

22. Good luck! daria.olijnyk@sistemic.co.uk