10 likes | 115 Views
TLR 2. TLR 1. TLR 6. TLR 4. TLR 5. MD2. CD36. MyD88. MAL. MyD88. CD14. IkB α. IKK α. IKK γ. IKK β. MAL. MyD88. p65. p50. IRAK4. IRAK1. TRAF6. Lipoproteins ECM components. LPS. Flagellin.
E N D
TLR 2 TLR 1 TLR 6 TLR 4 TLR 5 MD2 CD36 MyD88 MAL MyD88 CD14 IkBα IKKα IKKγ IKKβ MAL MyD88 p65 p50 IRAK4 IRAK1 TRAF6 Lipoproteins ECM components LPS Flagellin Cholesterol crystals IL1β IL1β NALP3 nucleus pro IL1β CARD ASC CASPASE 1 NFkB INFLAMMASOME cytosol