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Bone Morphogenetic Protein

Bone Morphogenetic Protein. By: Kim Stephens. What is Bone M orphogenetic P rotein?. Stimulates a patient's own cells to induce the formation of  bone and cartilage Recombinant human bone morphogenetic protein-2 , or rhBMP-2 Generates and repairs bone faster and more reliably

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Bone Morphogenetic Protein

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  1. Bone Morphogenetic Protein By: Kim Stephens

  2. What is Bone Morphogenetic Protein? • Stimulates a patient's own cells to induce the formation of bone and cartilage • Recombinant human bone morphogenetic protein-2, or rhBMP-2 • Generates and repairs bone faster and more reliably • Latest in bone growth enhancement

  3. Changing Points 1965: Dr. Marshall Urist, UCLA Department of Orthopedic Surgery in Los Angeles, CA discovered that the proteins needed to heal bone was inside bones 1997: First clinical trial with 11 patients 2001: New Hampshire Spine Institute

  4. Applications • Available in an oral form • A supplement for bone and joint health Regenerative Medicine: • Delivered to the site of the fracture • Released gradually to allow bone formation • Delivery in a purified collagen matrix

  5. Potential Applications • Osteoinductive characteristics make BMPs valuable as an alternative to bone grafts • Other methods of delivering BMPs to patients are undergoing evaluation • Non-skeletal tissues • Organogenesis

  6. Advantages Disadvantages BMP has only been FDA approved for one type of spinal fusion Expensive Side effects are not fully understood • Less pain, shorter hospital stays • More rapid return to a normal life • As effective as bone grafts • Eliminate the need for bone transplantation • Avoids the potential side effects and complications of bone harvesting or grafts

  7. Future • Use of BMP will potentially extend beyond skeletal disease and injury • Approval from the FDA to use BMP’s for dental work • Better understand these proteins and their benefits

  8. Works cited • http://www.spineuniverse.com/treatments/surgery/spinal-fusion-bone-morphogenetic-protein • http://www.spineuniverse.com/exams-tests/bone-morphogenetic-protein-bmp • http://www.medscape.com/viewarticle/446738_3 • http://www.zycalbio.com/research.htm • http://en.wikipedia.org/wiki/Bone_morphogenetic_protein • http://www.spine-health.com/treatment/spinal-fusion/bmp-bone-morphogenetic-proteins • http://www.freepatentsonline.com/4294753.html • http://webapps.css.udel.edu/biotech/rDNA.html • http://www.sciencedirect.com/science/article/pii/S0006291X07017147

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