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J.M.Nguta a ; J.M.Mbaria a

Bioavailability of cobalt and antihelmintic effects of Albendazole fortified with cobalt (Vermitan super) in sheep. J.M.Nguta a ; J.M.Mbaria a Department of Public Health, Pharmacology and Toxicology Faculty of Veterinary Medicine,

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J.M.Nguta a ; J.M.Mbaria a

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  1. Bioavailability of cobalt and antihelmintic effects of Albendazole fortified with cobalt (Vermitan super) in sheep J.M.Ngutaa; J.M.Mbariaa Department of Public Health, Pharmacology and Toxicology Faculty of Veterinary Medicine, College of Agriculture and Veterinary Sciences, University of Nairobi 7TH Biennial Scientific Conference

  2. Introduction: Why assess trace element status in Ruminants? Performance could be below expectation To determine the presence or prevalence of nutrient deficiencies and or toxicities in a population Evaluation of trace element bioavailability following oral supplementation For comparison of available supplements

  3. Introd.(Cont.) • Physiological functions are progressively affected by trace element deficiences/toxicities • Performance and animal health can be affected by trace element deficiences even before clinical signs are evident • Cobalt requirements of grazing sheep is approx. 0.1mg/kg/day. • Trace elements must be provided by the oral route to overcome deficiencies (Underwood, 1962; Marston, 1952).

  4. Introd.(Cont.) • The current study was designed to answer the following questions: • 1. How much of cobalt is available following adm. Of albendazole fortified with a known amount of cobalt? • 2.How efficacious is albendazole fortified with cobalt? • 3. Is the fortified formulation better than the non fortified formulation?

  5. Methodology • 16 twelve month old dopper cross castrate sheep(20-25kgs) obtained from Kiserian market were used. • Following acclimatization, they were divided into groups A(n=8; given normal albendazole) • And Group B (n=8; given fortified albendazole) • Blood samples for plasma preparation and liver samples were collected from both groups on days 0, 14 and 18 following sacrifice. • Cobalt levels were analysed using standard procedures

  6. Methodology(Cont.) • Feacal samples were collected on days 0 and 14 and egg counts estimated using Mcmaster technique.

  7. Statistical analysis • Repeated measurement test as per Gill John(1978)was used • Significance was noted at p<0.05.

  8. Results • High levels of strongyle eggs were observed from both groups on day 0. • No strongyle eggs were observed from both groups on day 14 post treatment.

  9. Results • Table 1: Mean cobalt levels in plasma of sheep following oral administration of vermitan (Group A) and vermitan super (Group B)

  10. Results • Table 2: Mean cobalt levels in liver of sheep following oral administration of vermitan (Group A) and vermitan super (Group B)

  11. Conclusion • Significant bioavailability of cobalt was observed in sheep dewormed with vermitan super as compared to those dewormed with normal vermitan both in the plasma and in the liver. • This study recommends fortification of albendazole with cobalt and the use of the formulation in those areas where cobalt is deficient. • Inclusion of cobalt did not interfere with the efficacy of albendazole

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